Evocarpine, Inhibitor
Evocarpine
Purity
98.00%
Synonyms
Evocarpine; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C23H33NO
SMILES
CCCC/C=C\CCCCCCCC(N(C)c1c2cccc1)=CC2=O
CAS Number
15266-38-3
Target & IC50
Antifection
Calcium Channel
cAMP
Calcium Channel
cAMP
In Vitro
The antimycobacterial and modulating activity of evodiamine (1), rutaecarpine (2) and Evocarpine (3) was tested on mycobacteria including three multidrug-resistant (MDR) clinical isolates of Mycobacterium tuberculosis. Antagonistic effects were concluded from fractional inhibitory concentration (FICI) values. Interaction energies of the compounds were calculated using GLUE docking module implemented in GRID. 1 and 2 exhibited weak inhibition of rapidly growing mycobacteria, however, 1 was active against Myco. tuberculosis H37Rv (MIC = 10 mg l(-1)) while 2 was inactive. Both 1 and 2 showed a marked antagonistic effect on the susceptibility of different mycobacterial strains to 3 giving FICI values between 5 and 9. The interaction energies between compounds 1 and 2 with compound 3 suggested the possibility of complex formation in solution[1]
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Related Product Information for Evocarpine, inhibitor
Evocarpine shows antimycobacterial, and vasorelaxant effects, it can inhibit Ca2+ influx through voltage-dependent calcium channels.
Product Categories/Family for Evocarpine, inhibitor
References
Antagonistic effects of indoloquinazoline alkaloids on antimycobacterial activity of evocarpine.J Appl Microbiol. 2015 Apr;118(4):864-72.
Antagonistic effects of indoloquinazoline alkaloids on antimycobacterial activity of evocarpine.J Appl Microbiol. 2015 Apr;118(4):864-72.
Characterization of in vitro metabolites of evocarpine in rat liver microsomes and their influence on antibacterial activityPlanta Medica, 2012, 78(11):1142-1142.
Antagonistic effects of indoloquinazoline alkaloids on antimycobacterial activity of evocarpine.J Appl Microbiol. 2015 Apr;118(4):864-72.
Characterization of in vitro metabolites of evocarpine in rat liver microsomes and their influence on antibacterial activityPlanta Medica, 2012, 78(11):1142-1142.
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Product Notes
The Evocarpine (Catalog #AAA5759871) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Evocarpine, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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