Structure
EB-3D, Inhibitor
EB-3D
Purity
>98% (HPLC)
Synonyms
EB-3D; ChoK inhibitor EB-3D; inhibitor
Purity/Purification
>98% (HPLC)
Target
ChoK
Receptor
ChoK
Chemical Name
1, 1'-(((ethane-1, 2-diylbis(oxy))bis(4, 1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridinium) bromide
SMILES
CN(C)C1=CC=[N+](C=C1)CC2=CC=C(C=C2)OCCOC3=CC=C(C=C3)C[N+]4=CC=C(C=C4)N(C)C.[Br-].[Br-]
Molecular Formula
C30H36Br2N4O2
CAS Number
1839150-63-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for EB-3D, inhibitor
EB-3D is a novel potent and selective choline kinase ChoKalpha inhibitor with IC50 of 1.0uM (purified ChoKalpha1), strongly impairs cell proliferation in a variety of different cancer cell lines; demonstrates in vitro antiproliferative effects against HeLa (IC50=79nM), RS4, 11 (IC50=45nM), A549 (IC50=27nM) and MDA-MB-231 (IC50=100nM); displays excellent antiproliferative activity against a wide cohort of T-leukemic cell lines with GI50 of 0.9nM (MOLT-16 cell)-479nM (CCRF-CEM), reduces the intracellular pool of PCho, but also inhibits the synthesis of choline-containing lipids; induces G0/G1 arrest that lead to apoptosis in leukemia cell lines; affects AMPK-mTOR signaling pathway, synergizes with both dexamethasone and L-asparaginase.
Product Categories/Family for EB-3D, inhibitor
References
1. Schiaffino-Ortega S, et al. Sci Rep. 2016 Mar 31; 6:23793.
2. Mariotto E, et al. Biochem Pharmacol. 2018 Jul 10. pii: S0006-2952 (18)30272-7.
2. Mariotto E, et al. Biochem Pharmacol. 2018 Jul 10. pii: S0006-2952 (18)30272-7.
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Product Notes
The EB-3D (Catalog #AAA3602841) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "EB-3D, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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