Structure
DS-1040 Tosylate, Inhibitor | DS-1040, inhibitor
DS-1040 Tosylate
Purity
98.00%
Synonyms
DS-1040 Tosylate; DS-1040; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
H2O: 100mg/mL (214.77mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C23H35N3O5S
SMILES
O=C(O)[C@H](CC1=CN([C@H]2CC[C@H](C)CC2)C=N1)CCCN.CC3=CC=C(S(=O)(O)=O)C=C3
CAS Number
1335138-89-0
Target & IC50
human TAFIa: ic50 5.92nM
rat TAFIa: ic50 8.01nM
rat TAFIa: ic50 8.01nM
In Vitro
DS-1040 Tosylate (0.0005-0.5mg/kg; IV) significantly reduces the microthrombi index at doses of 0.005mg/kg and greater. DS1040 (0.016, 0.031, 0.063, 0.13, 0.25, 0.50mg/kg; i.v.) increases plasma D-dimer levels in a dose-dependent manner in the microthrombosis model. ED50 and EDmax are 122 and 221nMol/L, respectively. DS-1040 (0.25, 0.5, 1, 2, 4, 8, 16mg/kg; orally) also increases plasma D-dimer levels. EC50 and ECmax values are 114 and 231nMol/L, respectively.
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for DS-1040, inhibitor
DS-1040 Tosylate is an oral active, selective thrombolytic inhibitor with IC50s of 5.92nM and 8.01nM for human and rat TAFIa, is an orally active, selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC50s of 5.92nM and 8.01nM for human and rat TAFIa. DS-1040 Tosylate is a fibrinolysis enhancer for thromboembolic diseases[1].
References
Noguchi K, et al. Fibrinolytic potential of DS-1040, a novel orally available inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa). Thromb Res. 2018 Aug;168:96-101.
Noguchi K, et al. Fibrinolytic potential of DS-1040, a novel orally available inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa). Thromb Res. 2018 Aug;168:96-101.
Noguchi K, et al. Fibrinolytic potential of DS-1040, a novel orally available inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa). Thromb Res. 2018 Aug;168:96-101.
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Product Notes
The DS-1040 (Catalog #AAA5753046) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "DS-1040 Tosylate, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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