Structure
CB-1158 dihydrochloride, Inhibitor | CB-1158, inhibitor
CB-1158 dihydrochloride
Purity
98.00%
Synonyms
CB-1158 dihydrochloride; INCB01158 dihydrochloride; CB-1158; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
H2O: 50mg/mL (138.87mM)
DMSO: <1mg/mL (insoluble or slightly soluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
DMSO: <1mg/mL (insoluble or slightly soluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C11H24BCl2N3O5
SMILES
O=C([C@@H](N)C)N1C[C@H](CCCB(O)O)[C@](N)(C(O)=O)C1.Cl.Cl
Target & IC50
Arginase 1: ic50 86nM
Arginase 2: ic50 296nM
Arginase 2: ic50 296nM
In Vitro
CB-1158 (100mg/kg, p.o., twice per day) decreases the number of myeloid cells and increases tumor-infiltrating cytotoxic cells in mice. CB-1158 in combination with LY 188011 inhibits tumor growth in mice bearing CT26 cancer cells.
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for CB-1158, inhibitor
CB-1158 dihydrochloride is an effective and orally active inhibitor of arginase (IC50s: 86nM and 296nM for recombinant human arginase 1 and 2).
References
Steggerda SM, et al. Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment. J Immunother Cancer. 2017 Dec 19;5(1):101.
Steggerda SM, et al. Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment. J Immunother Cancer. 2017 Dec 19;5(1):101.
Steggerda SM, et al. Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment. J Immunother Cancer. 2017 Dec 19;5(1):101.
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Product Notes
The CB-1158 (Catalog #AAA5752868) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CB-1158 dihydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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