Structure
Vinorelbine ditartrate, Inhibitor
Vinorelbine ditartrate
Purity
>98% (HPLC)
Synonyms
Vinorelbine ditartrate; KW-2307; Nor-5-anhydrovinblastine ditartrate; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=46mg/mL
Target
Microtubule/Tubulin
Receptor
Tubulin
Chemical Name
Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6, 7-didehydro-15-[(2R, 6R, 8S)-4-ethyl-1, 3, 6, 7, 8, 9-hexahydro-8-(methoxycarbonyl)-2, 6-methano-2H-azecino[4, 3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2beta, 3beta, 4beta, 5alpha, 12R, 19alpha)-, (2R, 3R)-2, 3-dih
SMILES
CCC1=CC2CC(C3=C(CN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC.C(C(C(=O)O)O)(C(=O)O)O.C(C(C(=O)O)O)(C(=O)O)O
Molecular Formula
C53H66N4O20
CAS Number
125317-39-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Vinorelbine ditartrate, inhibitor
Vinorelbine (KW-2307) is a vinca alkaloid chemotherapy agent that inhibits cancer cell mitosis through interaction with tubulin, inhibits HeLa cell proliferation with IC50 of 1.25nM; induces Hela mitotic block at the metaphase/anaphase transition with IC50 of 3.8nM, blocks cells exhibited aberrant spindles, consistent with induction of block by suppression of microtubule dynamics. Chemotherapeutic Agents Approved
Product Categories/Family for Vinorelbine ditartrate, inhibitor
References
1. Rahmani R, et al. Cancer Chemother Pharmacol. 1986; 16 (3):223-8.
2. Ngan VK, et al. Mol Pharmacol. 2001 Jul; 60 (1):225-32.
3. Monnet I, et al. Eur J Cancer. 1991; 27 (12):1716-7.
4. Rahmani R, et al. Cancer Res. 1984 Dec; 44 (12 Pt 1):5609-13.
2. Ngan VK, et al. Mol Pharmacol. 2001 Jul; 60 (1):225-32.
3. Monnet I, et al. Eur J Cancer. 1991; 27 (12):1716-7.
4. Rahmani R, et al. Cancer Res. 1984 Dec; 44 (12 Pt 1):5609-13.
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Product Notes
The Vinorelbine ditartrate (Catalog #AAA3601015) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Vinorelbine ditartrate, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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