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Immunohistochemistry (IHC) (Anti-PTGFR antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Rabbit FP / PTGFR Polyclonal Antibody | anti-FP antibody

Rabbit Polyclonal to Human FP / PTGFR

Gene Names
PTGFR; FP
Reactivity
Gorilla, Human
Predicted Reactivity: Gibbon, Monkey, Horse (at least 90% immunogen sequence identity)
Applications
Immunohistochemistry
Purity
Immunoaffinity Purified
Synonyms
FP / PTGFR; Polyclonal Antibody; Rabbit Polyclonal to Human FP / PTGFR; Anti-FP / PTGFR Antibody (Extracellular Domain) IHC-plus; PTGFR; PGF receptor; PGF2-alpha receptor; Prostaglandin F receptor (FP); FP; PGF2 alpha receptor; Prostaglandin F receptor; Prostanoid FP receptor; Human FP; anti-FP antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Gorilla, Human
Predicted Reactivity: Gibbon, Monkey, Horse (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Specificity
Human PTGFR. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
1 mg/ml (varies by lot)
Sequence Length
359
Applicable Applications for anti-FP antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes
IHC-P (20 ug/ml)
Target Species
Human
Immunogen Description
Synthetic 18 amino acid peptide from 1st extracellular domain of human PTGFR. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon, Monkey, Horse (94%); Marmoset, Mouse, Rat, Elephant, Panda, Bat, Dog, Rabbit, Pig (89%).
Immunogen Type
Synthetic peptide
Immunogen
FP / PTGFR antibody was raised against synthetic 18 amino acid peptide from 1st extracellular domain of human PTGFR. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon, Monkey, Horse (94%); Marmoset, Mouse, Rat, Elephant, Panda, Bat, Dog, Rabbit, Pig (89%); Turkey, Chicken, Platypus (83%).
Antigen Modification
Extracellular Domain
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-PTGFR antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC) (Anti-PTGFR antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-FP / PTGFR antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC) (Anti-FP / PTGFR antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-FP / PTGFR antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC) (Anti-FP / PTGFR antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-FP / PTGFR antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC) (Anti-FP / PTGFR antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Related Product Information for anti-FP antibody
The prostaglandin F2-alpha receptor is a member of the Prostanoid Receptor subfamily. Along with various other prostaglandin receptors, it mediates the effects of prostaglandin F(2-alpha) which include modulation of intraocular pressure, corpus luteum regression, and possibly uterine smooth muscle contraction. Alternative mRNA splicing gives rise to two isoforms, FP(A) and FP(B), that differ in their intracellular carboxyl termini and result in different mechanisms for receptor internalization.
Product Categories/Family for anti-FP antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
30,766 Da
NCBI Official Full Name
prostaglandin F2-alpha receptor isoform a
NCBI Official Synonym Full Names
prostaglandin F receptor (FP)
NCBI Official Symbol
PTGFR
NCBI Official Synonym Symbols
FP
NCBI Protein Information
prostaglandin F2-alpha receptor; PGF receptor; PGF2 alpha receptor; PGF2-alpha receptor; prostanoid FP receptor; prostaglandin F2 alpha receptor; prostaglandin receptor (2-alpha)
UniProt Protein Name
Prostaglandin F2-alpha receptor
Protein Family
UniProt Gene Name
PTGFR
UniProt Synonym Gene Names
PGF receptor; PGF2-alpha receptor
UniProt Entry Name
PF2R_HUMAN

NCBI Description

The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

PTGFR: Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 1p31.1

Cellular Component: integral to plasma membrane; cytoplasm; extracellular region; plasma membrane

Molecular Function: prostaglandin F receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of cell proliferation; response to lipopolysaccharide; parturition; negative regulation of apoptosis

Research Articles on FP

Similar Products

Product Notes

The FP ptgfr (Catalog #AAA243690) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal to Human FP / PTGFR reacts with Gorilla, Human Predicted Reactivity: Gibbon, Monkey, Horse (at least 90% immunogen sequence identity) and may cross-react with other species as described in the data sheet. AAA Biotech's FP / PTGFR can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin). IHC-P (20 ug/ml). Researchers should empirically determine the suitability of the FP ptgfr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FP / PTGFR, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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