Structure
CHMFL-KIT-031, Inhibitor
CHMFL-KIT-031
Purity
>98% (HPLC)
Synonyms
CHMFL-KIT-031; inhibitor
Purity/Purification
>98% (HPLC)
Target
c-Kit
Receptor
c-Kit
Chemical Name
(E)-3, 4, 5-trimethoxy-N-(2-oxo-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)amino)ethyl)benzamide
Molecular Formula
C26H25N5O5
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for CHMFL-KIT-031, inhibitor
CHMFL-KIT-031 is a highly selective KIT kinase primary V559D mutant inhibitor with IC50/Kd of 28/266nM, 10-20 fold selectivity over KIT wt; also displays 15-400-fold selectivity over other primary mutants such as L576P and secondary mutants including T670I, V654A as well as N822K and D816V; exhibits a selectivity S score (1) of 0.01 among 468 kinases/mutants in the KINOMEScan assay; inhibits the proliferation of BaF3-TEL-KIT-V559D cells with IC50 of 25nM, shows potent inhibitory efficacy for KIT V559D mediated signaling pathways in cell and anti-tumor activity in vivo.
Product Categories/Family for CHMFL-KIT-031, inhibitor
References
1. Yu K, et al. Oncotarget. 2017 Nov 15; 8 (67):111110-111118.
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Product Notes
The CHMFL-KIT-031 (Catalog #AAA3606971) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CHMFL-KIT-031, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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