Structure
CBL0137, Inhibitor
CBL0137
Purity
>98% (HPLC)
Synonyms
CBL0137; CBL-0137; CBL 0137; Curaxin CBL0137; CBLC 137; inhibitor
Purity/Purification
>98% (HPLC)
Target
c-Myc
Receptor
p53; NF-kappaB
Chemical Name
1, 1'-(9-(2-(isopropylamino)ethyl)-9H-carbazole-3, 6-diyl)bis(ethan-1-one)
SMILES
CC(NCCN1C2=C(C3=C1C=CC(C(C)=O)=C3)C=C(C(C)=O)C=C2)C
Molecular Formula
C21H24N2O2
CAS Number
1197996-80-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for CBL0137, inhibitor
CBL0137 (Curaxin CBL0137) is a histone chaperone FACT (facilitates chromatin transcription) and MYC signal inhibitor that markedly reduced tumor initiation and progression in vivo; simultaneously activates p53 and inhibits NF-kappaB without causing detectable genotoxicity, causes phosphorylation of p53 Ser (392) by CK2 and inhibition of NF-kappaB-dependent transcription in neuroblastoma cells; eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pancreatic cancer. Brain Cancer Phase 1 Clinical
Product Categories/Family for CBL0137, inhibitor
References
1. Carter DR, et al. Sci Transl Med. 2015 Nov 4; 7 (312):312ra176.
2. Gasparian AV, et al. Sci Transl Med. 2011 Aug 10; 3 (95):95ra74.
3. Burkhart C, et al. Oncotarget. 2014 Nov 30; 5 (22):11038-53.
2. Gasparian AV, et al. Sci Transl Med. 2011 Aug 10; 3 (95):95ra74.
3. Burkhart C, et al. Oncotarget. 2014 Nov 30; 5 (22):11038-53.
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Product Notes
The CBL0137 (Catalog #AAA3600708) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CBL0137, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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