Structure
Calphostin C, Inhibitor
Calphostin C
Purity
>98% (HPLC)
Synonyms
Calphostin C; UCN 1028C; PKF115-584; inhibitor
Purity/Purification
>98% (HPLC)
Target
PKC
Receptor
PKC
Chemical Name
1-(4, 9-dihydroxy-12-(2-(((4-hydroxyphenoxy)carbonyl)oxy)propyl)-2, 6, 7, 11-tetramethoxy-3, 10-dioxo-3, 10-dihydroperylen-1-yl)propan-2-yl benzoate
SMILES
CC(CC1=C2C3=C(C(=C(C4=C3C(=C5C2=C(C(=O)C=C5OC)C(=C1OC)O)C(=CC4=O)OC)O)OC)CC(C)OC(=O)OC6=CC=C(C=C6)O)OC(=O)C7=CC=CC=C7
Molecular Formula
C44H38O14
CAS Number
121263-19-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Calphostin C, inhibitor
A potent, selective and photo-dependent inhibitor of PKC with IC50 of 50nM; displays >1,000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase; inhibits cell growth and promotes apoptosis in HeLa S3 and MCF-7 cells with IC50 of 0.23 and 0.18uM, respectively; also inhibits phospholipase D1 and D2 (IC50=100nM); also blocks beta-catenin/Tcf transcriptional activity. Solid Tumors Discontinued
Product Categories/Family for Calphostin C, inhibitor
References
1. Sukhdeo K, et al. Proc Natl Acad Sci U S A. 2007 May 1; 104 (18):7516-21.
2. Kobayashi E, et al. J Antibiot (Tokyo). 1989 Oct; 42 (10):1470-4.
3. Sciorra VA, et al. Biochemistry. 2001 Feb 27; 40 (8):2640-6.
2. Kobayashi E, et al. J Antibiot (Tokyo). 1989 Oct; 42 (10):1470-4.
3. Sciorra VA, et al. Biochemistry. 2001 Feb 27; 40 (8):2640-6.
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Product Notes
The Calphostin C (Catalog #AAA3600793) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Calphostin C, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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