Chemical Structure
BIIB068, inhibitor
BIIB068
Purity
0.9805
Synonyms
BIIB068; inhibitor
Purity/Purification
0.9805
Form/Format
Solid
Solubility
DMSO: 30mg/ml(68.88mM)
Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
SMILES
O=C(N1CC(OC(C)C)C1)NCC2=CC=C(C3=NC(NC4=CN(C)N=C4)=NC=C3)C=C2C
Formula
C23H29N7O2
In vitro
BIIB068 inhibits B cell, neutrophil and monocyte activation in vitro, but not T cell responses.
CAS Number
1798787-27-5
Preparation and Storage
Store at 0-4 degree C for short term (days to weeks), or -20 degree C for long term (months).
Chemical Structure
Chemical Structure
Related Product Information for BIIB068, inhibitor
BIIB068 is an selective, reversible and orally active BTK inhibitor (IC50 = 1,Kd = 0.3). BIIB068 is 400 times more selective for BTK than other kinases.
Product Categories/Family for BIIB068, inhibitor
References
Ma B, Bohnert T, Otipoby K L, et al. Discovery of BIIB068: A Selective, Potent, Reversible Bruton's Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases[J]. Journal of Medicinal Chemistry, 2020, XXXX(XXX).
Similar Products
Product Notes
The BIIB068 (Catalog #AAA5765268) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BIIB068, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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