Western Blot (WB)
(RNF41 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the RNF41 antibody detected the RNF41 protein (arrow).)
Rabbit anti-Human RNF41 Polyclonal Antibody | anti-Rnf41 antibody
RNF41, CT (RNF41, FLRF, NRDP1, E3 ubiquitin-protein ligase NRDP1, RING finger protein 41)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Western Blot (WB)
(RNF41 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the RNF41 antibody detected the RNF41 protein (arrow).)
Western Blot (WB)
(RNF41 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the RNF41 antibody detected the RNF41 protein (arrow).)
NCBI and Uniprot Product Information
Uniprot Description
RNF41: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 and Negatively regulates MYD88-dependent production of proinflammatory cytokines but can promote TRIF-dependent production of type I interferon. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL- 3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages. Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state.
Protein type: EC 6.3.2.19; Ubiquitin ligase; EC 6.3.2.-; Ligase; Ubiquitin conjugating system
Molecular Function: interleukin-3 receptor binding; erythropoietin receptor binding; zinc ion binding; coenzyme F420-2 alpha-glutamyl ligase activity; metal ion binding; ribosomal S6-glutamic acid ligase activity; Ral GTPase binding; ubiquitin-protein ligase activity; protein binding; protein tag; acid-amino acid ligase activity; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity; coenzyme F420-0 gamma-glutamyl ligase activity; ligase activity
Biological Process: proteasomal protein catabolic process; regulation of myeloid cell differentiation; protein autoubiquitination; protein polyubiquitination; apoptosis; regulation of lymphocyte differentiation; protein ubiquitination; regulation of protein kinase B signaling cascade; negative regulation of cell proliferation; regulation of gene expression; regulation of MAPKKK cascade; autophagy; positive regulation of transcription factor activity; negative regulation of cell migration
Research Articles on Rnf41
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Product Notes
The Rnf41 rnf41 (Catalog #AAA6003440) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RNF41, CT (RNF41, FLRF, NRDP1, E3 ubiquitin-protein ligase NRDP1, RING finger protein 41) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's RNF41 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in Western Blot, ELISA Dilution: ELISA: 1:1,000 Western Blot: 1:100-500. Researchers should empirically determine the suitability of the Rnf41 rnf41 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RNF41, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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