Structure
BAY 41-8543, Inhibitor
BAY 41-8543
Purity
>98% (HPLC)
Synonyms
BAY 41-8543; BAY 418543; inhibitor
Purity/Purification
>98% (HPLC)
Target
Guanylate Cyclase
Receptor
Guanylate Cyclase
Chemical Name
2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3, 4-b]pyridin-3-yl]-5-(4-morpholinyl)-4, 6-pyrimidinediamine
SMILES
c1ccc(c(c1)Cn2c3c(cccn3)c(n2)c4nc(c(c(n4)N)N5CCOCC5)N)F
Molecular Formula
C21H21FN8O
CAS Number
256498-66-5
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for BAY 41-8543, inhibitor
BAY 41-8543 is an NO-independent sGC (soluble guanylyl cyclase) stimulator, inhibits collagen-mediated aggregation in washed human platelets (IC50=90nM); BAY 418543 is a potent direct stimulator of the cyclic GMP/PKG/VASP pathway in platelets and synergizes with NO over a wide range of concentrations. Hypertension Discontinued
Product Categories/Family for BAY 41-8543, inhibitor
References
1. Stasch JP, et al. Br J Pharmacol. 2002 Jan; 135 (2):333-43.
2. Stasch JP, et al. Br J Pharmacol. 2002 Jan; 135 (2):344-55.
3. Amirjanians M, et al. Oncotarget. 2017 May 2; 8 (18):29613-29624.
2. Stasch JP, et al. Br J Pharmacol. 2002 Jan; 135 (2):344-55.
3. Amirjanians M, et al. Oncotarget. 2017 May 2; 8 (18):29613-29624.
Similar Products
Product Notes
The BAY 41-8543 (Catalog #AAA3603772) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BAY 41-8543, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
