Structure
BAY 41-2272 Biochemical
BAY 41-2272
Purity
>98% (HPLC)
Synonyms
BAY 41-2272; BAY 412272; BAY41-2272; BAY 41-2272 biochemical
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 17.5mg/mL
Target
Guanylate Cyclase
Receptor
Guanylatecyclase
Chemical Name
4-Pyrimidinamine, 5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3, 4-b]pyridin-3-yl]
SMILES
NC1=NC(C2=NN(CC3=CC=CC=C3F)C4=NC=CC=C42)=NC=C1C5CC5
Molecular Formula
C20H17FN6
CAS Number
256376-24-6
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for BAY 41-2272 biochemical
BAY 41-2272 is a potent, NO-independent, orally available soluble guanylate cyclase (sGC) stimulator with IC50 of 0.3uM (relaxation of preconstricted aortic rings); targets the cysteine 238 and cysteine 243 region in the alpha1-subunit of sGC, sensitizes sGC to its physiological stimulator nitric oxide; potently unloads the heart, increases cardiac output, and preserves glomerular filtration rate without activation of the renin-angiotensin-aldosterone system in experimental congestive heart failure models. Heart Failure Discontinued
Product Categories/Family for BAY 41-2272 biochemical
References
1. Baracat JS, et al. Eur J Pharmacol. 2003 Sep 12; 477 (2):163-9.
2. Boerrigter G, et al. Circulation. 2003 Feb 11; 107 (5):686-9.
3. Stasch JP, et al. Nature. 2001 Mar 8; 410 (6825):212-5.
4. Straub A, et al. Bioorg Med Chem Lett. 2001 Mar 26; 11 (6):781-4.
2. Boerrigter G, et al. Circulation. 2003 Feb 11; 107 (5):686-9.
3. Stasch JP, et al. Nature. 2001 Mar 8; 410 (6825):212-5.
4. Straub A, et al. Bioorg Med Chem Lett. 2001 Mar 26; 11 (6):781-4.
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Product Notes
The BAY 41-2272 (Catalog #AAA3603769) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BAY 41-2272, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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