Chemical Structure
AZD5582 acetate, Inhibitor | AZD5582, inhibitor
AZD5582 acetate (1258392-53-8 free base)
Purity
0.9776
Synonyms
AZD5582 acetate; AZD5582 acetate (1258392-53-8 free base); AZD5582; inhibitor
Purity/Purification
0.9776
Form/Format
Solid
Solubility
(<1mg/ml refers to the product slightly soluble or insoluble)
SMILES
C[C@H](NC)C(N[C@H](C(N1CCC[C@H]1C(N[C@@H]2[C@H](OCC#CC#CCO[C@@H]3CC4=CC=CC=C4[C@@H]3NC([C@@H]5CCCN5C([C@@H](NC([C@@H](NC)C)=O)C6CCCCC6)=O)=O)CC7=CC=CC=C27)=O)=O)C8CCCCC8)=O.CC(O)=O
Formula
C60H82N8O10
In vitro
AZD5582 (intravenous injection; 0.1-3.0 mg/kg; once a week; 2 weeks) causes degradation of cIAP1 and caspase 3 cleavage in tumor cells, and after a two-week treatment, the tumors largely resolved. When the mice are given a medium dose (0.5 mg/kg) of AZD5582, cIAP1 degrades after administration, but it takes a while time to reach apoptosis-inducing effect[1].
Preparation and Storage
Store at 0-4 degree C for short term (days to weeks), or-20 degree C for long term (months)
Chemical Structure
Chemical Structure
Related Product Information for AZD5582, inhibitor
AZD5582 acetate is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1,cIAP2,and XIAP with IC50s of 15,21,and 15,respectively. AZD5582 induces apoptosis.
References
Hennessy EJ, et al. Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582). J Med Chem. 2013 Dec 27;56(24):9897-919.
Qin Hao, et al. IF-gamma and Smac mimetics synergize to induce apoptosis of lung cancer cells in a TNFalpha-independent manner,Cancer Cell Int. 2018; 18: 84.
Qin Hao, et al. IF-gamma and Smac mimetics synergize to induce apoptosis of lung cancer cells in a TNFalpha-independent manner,Cancer Cell Int. 2018; 18: 84.
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Product Notes
The AZD5582 (Catalog #AAA5764656) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AZD5582 acetate, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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