Structure
DEBIO 1143 Biochemical
DEBIO 1143
Purity
>98% (HPLC)
Synonyms
DEBIO 1143; AT-406; DEBIO1143; SM406; ARRY-334543; D1143; DEBIO 1143 biochemical
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 93mg/mL (165.6mM)
Ethanol: 93mg/mL (165.6mM)
Water: <1mg/mL (<1mg/mL refers to the product slightly soluble or insoluble)
Ethanol: 93mg/mL (165.6mM)
Water: <1mg/mL (<1mg/mL refers to the product slightly soluble or insoluble)
Target
Other Targets
Receptor
cIAP1-BIR3; cIAP2-BIR3; XIAP-BIR3
Chemical Name
(5S, 8S, 10aR)-N-benzhydryl-5-((S)-2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1, 2-a][1, 5]diazocine-8-carboxamide
SMILES
CC(C)CC(=O)N1CCC2CCC(N2C(=O)C(C1)NC(=O)C(C)NC)C(=O)NC(C3=CC=CC=C3)C4=CC=CC=C4
Molecular Formula
C32H43N5O4
CAS Number
1071992-99-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for DEBIO 1143 biochemical
DEBIO 1143 (AT-406, DEBIO-1143, SM406, ARRY-334543, D1143) is potent, orally active Smac mimetic that antagonizes cIAP1, cIAP2 and XIAP with Ki of 66.4, 1.9 and 5.1nM, respectively; effectively antagonizes XIAP BIR3 protein in cell-free functional assays, induces rapid degradation of cellular cIAP1 protein, and inhibits cancer cell growth in various human cancer cell lines; effectively induces apoptosis and causes complete inhibition of tumor growth apoptosis in xenograft tumors. Ovarian Cancer Phase 2 Clinical
Product Categories/Family for DEBIO 1143 biochemical
References
1. Cai Q, et al. J Med Chem. 2011 Apr 28; 54 (8):2714-26.
2. Langdon CG, et al. Oncotarget. 2015 Nov 10; 6 (35):37410-25.
3. Tao Z, et al. Clin Cancer Res. 2018 Oct 23. doi: 10.1158/1078-0432.
4. Thibault B, et al. Sci Rep. 2018 Dec 14; 8 (1):17862.
2. Langdon CG, et al. Oncotarget. 2015 Nov 10; 6 (35):37410-25.
3. Tao Z, et al. Clin Cancer Res. 2018 Oct 23. doi: 10.1158/1078-0432.
4. Thibault B, et al. Sci Rep. 2018 Dec 14; 8 (1):17862.
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Product Notes
The DEBIO 1143 (Catalog #AAA3600293) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "DEBIO 1143, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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