Structure
Avanbulin, Inhibitor
Avanbulin
Purity
>98% (HPLC)
Synonyms
Avanbulin; BAL27862; BAL-27862; inhibitor
Purity/Purification
>98% (HPLC)
Target
Microtubule/Tubulin
Receptor
Microtubule/Tubulin
Chemical Name
3-[(4-{1-[2-(4-aminophenyl)-2-oxoethyl]-1H-benzimidazol-2-yl}-1, 2, 5-oxadiazol-3-yl)amino]propanenitrile
SMILES
N#CCCNC1=NON=C1C2=NC3=CC=CC=C3N2CC(C4=CC=C(N)C=C4)=O
Molecular Formula
C20H17N7O2
CAS Number
798577-91-0
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Avanbulin, inhibitor
Avanbulin (BAL27862, BAL-27862) is a novel microtubule-destabilizing agent that potently inhibits tubulin assembly at 37 degree C with IC50 of 1.4uM in tubulin-binding assays; potentli bindis to unassembled tubulin with a stoichiometry of 1 mol/mol tubulin and a dissociation constant of 244 +/- 30nM, BAL27862 bound to tubulin independently of vinblastine, without the formation of tubulin oligomers; inhibits tumor cell proliferation through activation of the spindle assembly checkpoint, inhibits EB1-dependent migration and invasion and promotes differentiation of glioblastoma stem-like cells both in vitro and in vivo.
Product Categories/Family for Avanbulin, inhibitor
References
1. Prota AE, et al. J Mol Biol. 2014 Apr 17; 426 (8):1848-60.
2. Kolb EA, et al. Pediatr Blood Cancer. 2015 Jun; 62 (6):1106-9.
3. Bergi¨s R, et al. Mol Cancer Ther. 2016 Nov; 15 (11):2740-2749.
4. Dudka D, et al. Nat Commun. 2018 May 23; 9 (1):2042.
2. Kolb EA, et al. Pediatr Blood Cancer. 2015 Jun; 62 (6):1106-9.
3. Bergi¨s R, et al. Mol Cancer Ther. 2016 Nov; 15 (11):2740-2749.
4. Dudka D, et al. Nat Commun. 2018 May 23; 9 (1):2042.
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Product Notes
The Avanbulin (Catalog #AAA3605988) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Avanbulin, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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