Chemical Structure
Aprepitant (MK-0869), Inhibitor
Aprepitant (MK-0869)
Purity
>98%
Synonyms
Aprepitant (MK-0869); MK0869; MK-869; L-754030; Emend; inhibitor
Purity/Purification
>98%
Form/Format
Powder
Concentration
0.1 mM: 18.71 mL (1 mg); 93.56 mL (5 mg); 187.13mL (10 mg)
0.5 mM: 3.74 mL (1 mg); 18.71 mL (5 mg); 37.43 mL (10 mg)
1 mM: 1.87 mL (1 mg); 9.36 mL (5 mg); 18.71 mL (10 mg)
5 mM: 0.37 mL (1 mg); 1.87 mL (5 mg); 3.74 mL (10 mg) (varies by lot)
0.5 mM: 3.74 mL (1 mg); 18.71 mL (5 mg); 37.43 mL (10 mg)
1 mM: 1.87 mL (1 mg); 9.36 mL (5 mg); 18.71 mL (10 mg)
5 mM: 0.37 mL (1 mg); 1.87 mL (5 mg); 3.74 mL (10 mg) (varies by lot)
CAS Number
170729-80-3
Formula
C23H21F7N4O3
SMILES
C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NC(=O)NN3)C4=CC=C(C=C4)F
Actions
Antagonist
In Vivo Solvent
30% PEG400/0.5% Tween80/5% propylene glycol
Solubility (DMSO)
107 mg/mL (200.21 mM)
Solubility (Ethanol)
15 mg/mL (28.06 mM)
Solubility (in vivo)
30 mg/mL
Solubility (Water)
<1 mg/mL (<1 mM)
Availability
We cannot ship this item to Switzerland, Italy, Germany, France and Austria.
Preparation and Storage
at -20 degree C 3 years Powder
Chemical Structure
Chemical Structure
Related Product Information for Aprepitant (MK-0869), inhibitor
Aprepitant is classified as an NK1 antagonist. Aprepitant has been shown to inhibit both the acute and delayed emesis induced by cytotoxic chemotherapeutic drugs by blocking substance P landing on receptors in the brains neurons. It has also been shown to increase the activity of the 5-HT3 receptor antagonists ondansetron and the corticosteroid dexamethasone, which are also used to prevent nausea and vomiting caused by chemotherapy.
References
Kodji X, .et al. Sensory nerves mediate spontaneous behaviors in addition to inflammation in a murine model of psoriasis, FASEB J, 2018, Sep 11:fj201800395RR PMID: 30204499
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Product Notes
The Aprepitant (MK-0869) (Catalog #AAA385136) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Aprepitant (MK-0869), Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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