Structure
Agnuside, Inhibitor
Agnuside
Purity
98.00%
Synonyms
Agnuside; chasteberry oil; inhibitor
Purity/Purification
98.00%
Form/Format
Powder
Formula
C22H26O11
CAS
11027-63-7
Smiles
OC[C@H]1O[C@@H](O[C@@H]2OC=C[C@H]3[C@H](O)C=C(COC(=O)c4ccc(O)cc4)[C@@H]23)[C@H](O)[C@@H](O)[C@@H]1O
Receptor (IC50)
COX-2: 0.026mg/ml
Solubility
DMSO: 10mg/mL
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Preparation and Storage
Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
Structure
Structure
Related Product Information for Agnuside, inhibitor
Agnuside inhibits COX-2 (IC50: 0.026mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-glycoprotein (P-gp) ATPase activity at concentrations of 5, 25, and 100uM, respectively.
Product Categories/Family for Agnuside, inhibitor
References
1. Suksamrarn A, et al. Iridoids with anti-inflammatory activity from Vitex peduncularis. Planta Med. 2002 Jan;68 (1):72-3.
2. Hu Y, et al. Evaluation of the estrogenic activity of the constituents in the fruits of Vitex rotundifolia L. for the potential treatment of premenstrual syndrome. J Pharm Pharmacol. 2007 Sep;59 (9):1307-12.
3. Okuyama E, et al. Pharmacologically active components of viticis fructus (Vitex rotundifolia). II. The components having analgesic effects. Chem Pharm Bull (Tokyo). 1998 Apr;46 (4):655-62.
4. Pandey A, et al. Anti-arthritic activity of agnuside mediated through the down-regulation of inflammatory mediators and cytokines. Inflamm Res. 2012 Apr;61 (4):293-304.
5. Najar IA, et al. Modulation of P-glycoprotein ATPase activity by some phytoconstituents. Phytother Res. 2010 Mar;24 (3):454-8.
2. Hu Y, et al. Evaluation of the estrogenic activity of the constituents in the fruits of Vitex rotundifolia L. for the potential treatment of premenstrual syndrome. J Pharm Pharmacol. 2007 Sep;59 (9):1307-12.
3. Okuyama E, et al. Pharmacologically active components of viticis fructus (Vitex rotundifolia). II. The components having analgesic effects. Chem Pharm Bull (Tokyo). 1998 Apr;46 (4):655-62.
4. Pandey A, et al. Anti-arthritic activity of agnuside mediated through the down-regulation of inflammatory mediators and cytokines. Inflamm Res. 2012 Apr;61 (4):293-304.
5. Najar IA, et al. Modulation of P-glycoprotein ATPase activity by some phytoconstituents. Phytother Res. 2010 Mar;24 (3):454-8.
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Product Notes
The Agnuside (Catalog #AAA5751194) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Agnuside, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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