Testing Data
APICIDIN, Inhibitor
APICIDIN
Purity
>=98%
Synonyms
APICIDIN; Cyclo[(2S)-2-Amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]; inhibitor
Purity/Purification
>=98%
Specific Activity
HDAC Inhibitor
CAS Registry Number
183506-66-3
Molecular Formula
C34H49N5O6
Melting Point
190 degree C
Solubility
Soluble in DMSO (10mg/ml); or ethanol (1mg/ml)
Preparation and Storage
Stable for at least 1 year after receipt when stored, as supplied, at -20 degree C. St degree Ck solutions are stable for up to 3 months at -20 degree C.
Testing Data
Testing Data
Related Product Information for APICIDIN, inhibitor
Cyclopeptide inhibitor of histone deactylases (HDACs)1. Inhibits HeLa cell proliferation (IC50=50-100 nM) and induces reversible transcriptional activation of p21 (WAF1)2. Decreases HIF1alpha protein levels and transcriptional activity in human and mouse tumor cell lines3. Cell permeable.
Product Categories/Family for APICIDIN, inhibitor
References
1. SJ Darkin-Rattray et al. Proc. Natl. Acad. Sci. USA. 1996 93:13143
2. JW Han et al. Cancer Res. 2000 60:6068
3. SH Kim et al. Oncol. Rep. 2007 17:647
2. JW Han et al. Cancer Res. 2000 60:6068
3. SH Kim et al. Oncol. Rep. 2007 17:647
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Product Notes
The APICIDIN (Catalog #AAA516372) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "APICIDIN, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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