ABT-737, Inhibitor

ABT-737

Cat. Num. AAA385210

• Purity: >98%
• Synonyms: ABT-737; inhibitor

• Purity/Purification: >98%
• Form/Format: Powder
• Concentration: 0.1 mM: 12.29 mL (1 mg); 61.47 mL (5 mg); 122.94mL (10 mg); 0.5 mM: 2.46 mL (1 mg); 12.29 mL (5 mg); 24.59 mL (10 mg); 1 mM: 1.23 mL (1 mg); 6.15 mL (5 mg); 12.29 mL (10 mg); 5 mM: 0.25 mL (1 mg); 1.23 mL (5 mg); 2.46 mL (10 mg) (varies by lot)

• CAS Number: 852808-04-9
• Formula: C42H45ClN6O5S2
• SMILES: CN(C)CC[C@H](CSC1=CC=CC=C1)NC2=C(C=C(C=C2)S(=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCN(CC4)CC5=CC=CC=C5C6=CC=C(C=C6)Cl)[N+](=O)[O-]
• Actions: Inhibitor
• In Vivo Solvent: 30% propylene glycol, 5% Tween 80, 65% D5W
• Solubility (DMSO): 100 mg/mL (122.93 mM)
• Solubility (Ethanol): <1 mg/mL (<1 mM)
• Solubility (in vivo): 30 mg/mL
• Solubility (Water): <1 mg/mL (<1 mM)
• Availability: We cannot ship this item to Switzerland, Italy, Germany, France and Austria.
• Preparation and Storage: at -20 degree C 3 years Powder

Chemical Structure

Related Product Information for ABT-737, inhibitor

ABT-737 is a pan-Bcl-2 inhibitor. IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to <10 ??M (Nalm-6, K562 and HL-60).

References

Meikle V, .et al. A protein complex from human milk enhances the activity of antibiotics and drugs against Mycobacterium tuberculosis, Antimicrob Agents Chemother, 2018, Nov 12. pii: AAC.01846-18 PMID: 30420480
Chauhan D, .et al. BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages, Cell Rep, 2018, Nov 27;25(9):2354-2368.e5 PMID: 30485805
Jose Mario Gonzalez-Meljem, .et al. Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma, Nat Commun, 2017, 8: 1819 PMID: 29180744
Zhang C, .et al. Sorafenib targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1-Parkin pathway and modulate cellular drug response, J Biol Chem, 2017, Sep 8;292(36):15105-15120 PMID: 28673964
Eun Young Kim, .et al. ABT-737 Synergizes with Cisplatin Bypassing Aberration of Apoptotic Pathway in Non-small Cell Lung Cancer, Neoplasia, 2017, Apr; 19(4): 354-363 PMID: 28319809
Masayoshi Toge, .et al. Critical contribution of MCL-1 in EMT-associated chemo-resistance in A549 non-small cell lung cancer., Int J Oncol., 2015, Apr;46(4):1844-8 PMID: 25647738