Inner centromere protein (INCENP) Recombinant Protein | INCENP recombinant protein

Recombinant Chicken Inner centromere protein (INCENP), partial

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Inner centromere protein (INCENP); Recombinant Chicken Inner centromere protein (INCENP); partial; INCENP recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 839

• Species: Chicken
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 45384506
• NCBI GeneID: 396270
• NCBI Accession #: NP_990661.1
• NCBI GenBank Nucleotide #: NM_205330.1
• UniProt Accession #: P53352
• Molecular Weight: 96,367 Da
• NCBI Official Full Name: inner centromere protein
• NCBI Official Synonym Full Names: inner centromere protein
• NCBI Official Symbol: INCENP
• NCBI Protein Information: inner centromere protein
• UniProt Protein Name: Inner centromere protein
• Protein Family: Inner centromere protein
• UniProt Gene Name: INCENP

Uniprot Description

Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB toward substrates near microtubules. The flexibility of the SAH domain is proposed to allow AURKB to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin. Activates AURKB.