IL-3 Receptor Subunit Alpha/IL-3RA/CD123 Recombinant Protein | IL-3 recombinant protein

Recombinant Human IL-3 Receptor Subunit Alpha/IL-3RA/CD123 (C-6His)

Cat. Num. AAA2569235

• Gene Names: IL3RA; IL3R; CD123; IL3RX; IL3RY; IL3RAY; hIL-3Ra
• Purity: >95% as determined by reducing SDS-PAGE
• Synonyms: IL-3 Receptor Subunit Alpha/IL-3RA/CD123; Recombinant Human IL-3 Receptor Subunit Alpha/IL-3RA/CD123 (C-6His); Interleukin-3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha; IL-3RA; CD123; IL-3 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from a 0.2um filtered solution of PBS, pH7.4.
• Sequence: Thr19-Arg305

• Species: Human
• Tag: C-6His
• Endotoxin: <1.0EU per ug as determined by the LAL method.
• Protein Construction: Recombinant Human Interleukin-3 Receptor Subunit Alpha is produced by our Mammalian expression system and the target gene encoding Thr19-Arg305 is expressed with a 6His tag at the C-terminus.
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

SDS-Page

Related Product Information for IL-3 recombinant protein

CD123, also known as Interleukin-3 receptor subunit alpha, belongs to the type I cytokine receptor family. In mouse, there are two classes of high-affinity IL3 receptors. One contains an IL3-specific beta subunit and the other contains the beta subunit also shared by high-affinity IL5 and GM-CSF receptors. CD123 stimulates the proliferation and differentiation of hemopoietic cells including the pluripotent hematopoietic stem cells as well as various lineage?committed cells. CD123 is a heterodimer consisting of an alpha and a beta subunit. The alpha subunit alone binds IL?3 with low affinity. The beta subunit does not bind IL?3 by itself but is required for the high?affinity binding of IL?3 to the heterodimeric receptor complex.

Product Categories/Family for IL-3 recombinant protein

Signal Transduction; immunology

NCBI and Uniprot Product Information

• NCBI GI #: 417184
• NCBI GeneID: 3563
• UniProt Accession #: P26951; Q5HYQ7; Q5HYQ8; Q9UEH7; A8K3F3; B9VI81
• Molecular Weight: 34,466 Da
• NCBI Official Full Name: Interleukin-3 receptor subunit alpha
• NCBI Official Synonym Full Names: interleukin 3 receptor, alpha (low affinity)
• NCBI Official Symbol: IL3RA
• NCBI Official Synonym Symbols: IL3R; CD123; IL3RX; IL3RY; IL3RAY; hIL-3Ra
• NCBI Protein Information: interleukin-3 receptor subunit alpha; IL-3RA; IL-3R-alpha; CD123 antigen; IL-3R subunit alpha; IL-3 receptor subunit alpha; IL-3 receptor alpha SP2 isoform
• UniProt Protein Name: Interleukin-3 receptor subunit alpha
• UniProt Gene Name: IL3RA
• UniProt Synonym Gene Names: IL3R; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha; IL-3RA
• UniProt Entry Name: IL3RA_HUMAN

NCBI Description

The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012]

Uniprot Description

IL3RA: This is a receptor for interleukin-3. Belongs to the type I cytokine receptor family. Type 5 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: Xp22.3 or Yp11.3

Cellular Component: plasma membrane; integral to membrane

Molecular Function: interleukin-3 receptor activity