Interleukin-36b/IL-36b/IL1F8 Recombinant Protein | IL-36b/IL1F8 recombinant protein

Recombinant Mouse Interleukin-36b/IL-36b/IL1F8 Protein

Cat. Num. AAA2553563

• Gene Names: Il1f8; Il36b; 2310043N20Rik
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Interleukin-36b/IL-36b/IL1F8; Recombinant Mouse Interleukin-36b/IL-36b/IL1F8 Protein; Il36b; Interleukin-36 beta; Interleukin-1 family member 8; IL-1F8; Fil1e; Il1f8; IL-36b/IL1F8 recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM Tris, 150mM NaCl, 1mM EDTA, pH 8.0.
• Sequence Positions: Ser31-Lys183
• Sequence Length: 183

• Species: Mouse
• Endotoxin: <1.0 EU per mug as determined by LAL test.
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for IL-36b/IL1F8 recombinant protein

Mouse Interleukin 36 beta (IL-36B)is a member of the IL-1 family of proteins. It is a cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. IL-36B is synthesized in several cells including resting and activated monocytes, and B cells. The receptor for IL-36 beta is thought to be a combination of IL-1 Rrp2 and IL-1 RAcP. Interleukin 36 beta is one part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Interleukin 36 beta are involved in a number of fundamental biological processes such as stimulating production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes, inducing expression of a number of antimicrobial peptides including beta-defensin 4 and beta-defensin 103 as well as a number of matrix metalloproteases, inducing the production of proinflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23, and activating p38 MAPK phosphorylation in BMDCs.Moreover, interleukin 36 beta may be involved in skin inflammatory response by acting on keratinocytes, dendritic cells, and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. It plays an important role in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II and inducing the production of IFN-gamma, IL-4 and IL-17 by T helper 1 (Th1) cells, cultured CD4+ T cells and splenocytes.

NCBI and Uniprot Product Information

• NCBI GI #: 118601193
• NCBI GeneID: 69677
• NCBI Accession #: NP_081439.1
• NCBI GenBank Nucleotide #: NM_027163.4
• UniProt Accession #: Q9D6Z6; Q8R461
• Molecular Weight: Molecular Mass: 17.6 kDa; Actual Protein Molecular Mass: 16 kDa
• NCBI Official Full Name: interleukin-36 beta
• NCBI Official Synonym Full Names: interleukin 1 family, member 8
• NCBI Official Symbol: Il1f8
• NCBI Official Synonym Symbols: Il36b; 2310043N20Rik
• NCBI Protein Information: interleukin-36 beta
• UniProt Protein Name: Interleukin-36 beta
• UniProt Gene Name: Il36b
• UniProt Synonym Gene Names: Fil1e; Il1f8; IL-1F8

Uniprot Description

Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensin 4 and beta-defensin 103 as well as a number of matrix metalloproteases (). Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. Induces the production of proinflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23, and activates p38 MAPK phosphorylation in BMDCs. Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by T-helper 1 (Th1) cells, cultured CD4+ T-cells and splenocytes.