Mouse Cytokine receptor common subunit gamma ELISA Kit | Il2rg elisa kit

Mouse Cytokine receptor common subunit gamma ELISA Kit

Cat. Num. AAA2882947

• Gene Names: Il2rg; gc; p64; [g]c; CD132; gamma(c)
• Reactivity: Mouse
• Synonyms: Cytokine receptor common subunit gamma; Mouse Cytokine receptor common subunit gamma ELISA Kit; Interleukin-2 receptor subunit gamma; IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG; gammaC; p64; Il2rg; CD132; Il2rg elisa kit

• Reactivity: Mouse
• Sequence Length: 369

• Assay Type: Sandwich
• Detection Range: 78-5000 pg/mL
• Sensitivity: 41.3 pg/mL
• Intra-Assay CV: <=7.4%
• Inter-Assay CV: <=10.0%
• Recovery: 84%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 7305181
• NCBI GeneID: 16186
• NCBI Accession #: NP_038591.1
• NCBI GenBank Nucleotide #: NM_013563.4
• UniProt Accession #: P34902
• Molecular Weight: 42,241 Da
• NCBI Official Full Name: cytokine receptor common subunit gamma isoform a
• NCBI Official Synonym Full Names: interleukin 2 receptor, gamma chain
• NCBI Official Symbol: Il2rg
• NCBI Official Synonym Symbols: gc; p64; [g]c; CD132; gamma(c)
• NCBI Protein Information: cytokine receptor common subunit gamma
• UniProt Protein Name: Cytokine receptor common subunit gamma
• Protein Family: Cytokine receptor
• UniProt Gene Name: Il2rg
• UniProt Synonym Gene Names: IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG
• UniProt Entry Name: IL2RG_MOUSE

NCBI Description

This gene encodes a transmembrane protein that is a common subunit of several interleukin receptor complexes. These receptors are comprised of alpha and beta subunits in addition to this gamma subunit. Signalling through this pathway in important in immune cell differentiation and function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

Uniprot Description

IL2RG: Common subunit for the receptors for a variety of interleukins. Defects in IL2RG are the cause of severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell- negative (XSCID); also known as agammaglobulinemia Swiss type. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell- mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. Defects in IL2RG are the cause of X-linked combined immunodeficiency (XCID). XCID is a less severe form of X-linked immunodeficiency with a less severe degree of deficiency in cellular and humoral immunity than that seen in XSCID. Belongs to the type I cytokine receptor family. Type 5 subfamily.

Protein type: Receptor, cytokine; Membrane protein, integral

Cellular Component: external side of plasma membrane; integral to membrane; membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-2 binding

Biological Process: positive regulation of B cell differentiation; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; positive regulation of lymphocyte differentiation; positive regulation of T cell differentiation in the thymus; regulation of gene expression