Interleukin-21/IL-21 Recombinant Protein | IL-21 recombinant protein

Recombinant Mouse Interleukin-21/IL-21 Protein (N-6His)

Cat. Num. AAA2553554

• Gene Names: Il21; IL-21
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Interleukin-21/IL-21; Recombinant Mouse Interleukin-21/IL-21 Protein (N-6His); Interleukin-21; IL-21; IL21; Il21; IL-21 recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
• Sequence Positions: Pro25-Ser146
• Sequence Length: 146

• Species: Mouse
• Endotoxin: <1.0 EU per mug as determined by LAL test.
• Fusion Tag: N-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for IL-21 recombinant protein

Interleukin-21(IL-21) is an approximately 14 kDa cytokine which belongs to the IL-15/IL-21 family. Mature mouse IL-21 shares 66%, 59%, 58%, and 88% aa sequence identity with mature canine, human, rabbit, and rat IL-21, respectively. IL-21 is produced by activated T follicular helper cells (Tfh), Th17 cells, and NKT cells. It exerts its biological effects through a heterodimeric receptor complex (IL-21 specific IL-21 R). IL-21 is a cytokine that has potent regulatory effects on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells. This cytokine induces cell division/proliferation in its target cells. It is required for the migration of dendritic cells to draining lymph nodes.It co-stimulates the activation, proliferation, and survival of CD8+ T cells and NKT cells and promotes Th17 cell polarization. It blocks the generation of regulatory T cells and their suppressive effects on CD4+ T cells.

NCBI and Uniprot Product Information

• NCBI GI #: 11140821
• NCBI GeneID: 60505
• NCBI Accession #: NP_068554.1
• NCBI GenBank Nucleotide #: NM_021782.3
• UniProt Accession #: Q9ES17
• Molecular Weight: Molecular Mass: 14.4 kDa; Actual Protein Molecular Mass: 17 kDa
• NCBI Official Full Name: interleukin-21 isoform 2
• NCBI Official Synonym Full Names: interleukin 21
• NCBI Official Symbol: Il21
• NCBI Official Synonym Symbols: IL-21
• NCBI Protein Information: interleukin-21
• UniProt Protein Name: Interleukin-21
• UniProt Gene Name: Il21
• UniProt Synonym Gene Names: IL-21

Uniprot Description

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.