Interleukin-21 Receptor Active Protein | IL21R active protein

Recombinant Human Interleukin-21 Receptor Protein

Cat. Num. AAA2556667

• Gene Names: IL21R; NILR; CD360; IMD56
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Interleukin-21 Receptor; Recombinant Human Interleukin-21 Receptor Protein; Interleukin-21 receptor; IL-21 receptor; IL-21R; CD360; IL21R active protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
• Sequence Length: 538

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fragment: Cys20-Pro236
• Fusion Tag: C-6His
• Activity: Measured by its ability to bind human IL-21 in a functional ELISA. 2. Measured by its ability to inhibit IL21-induced Interferon gamma secretion by human natural killer lymphoma NK-92 cells. The ED50 for this effect is typically 1-5 ng/ml in the presence of 10 ng/ml of recombinant human IL23. Measured by its ability to inhibit IL21-induced Interferon gamma secretion by human natural killer lymphoma NK-92 cells. The ED50 for this effect is typically 50-200 pg/mL in the presence of 1 ng/ml of recombinant human IL21.
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days.; Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

SDS-Page

Related Product Information for IL21R active protein

Protein Construction: Recombinant Human Interleukin-21 Receptor is produced by our Mammalian expression system and the target gene encoding Cys20-Pro236 is expressed with a 6His tag at the C-terminus.

Background: Interleukin-21 receptor is also known as IL-21 receptor, IL-21R, CD360. In humans, it is encoded by the IL21R gene. It belongs to the type I cytokine receptor family. Type 4 subfamily contains 2 fibronectin type-III domains. Interleukin-21 receptor is selectively expressed in lymphoid tissues and highly expressed in thymus and spleen. IL-21 is produced by CD4+ T cells in response to antigenic stimulation. Its action enhances antigen-specific responses of immune cells. The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells. It also promotes the anti-tumor activity of CD8+ T-cells and NK cells.

NCBI and Uniprot Product Information

• NCBI GI #: 11141869
• NCBI GeneID: 50615
• NCBI Accession #: NP_068570.1
• NCBI GenBank Nucleotide #: NM_021798.3
• UniProt Accession #: Q9HBE5; Q96HZ1; Q9HB91; A8K9E8; D3DWF7
• Molecular Weight: Molecular Mass: 26.0kDa; Actual Protein Molecular Mass: 46kDa
• NCBI Official Full Name: interleukin-21 receptor isoform 1
• NCBI Official Synonym Full Names: interleukin 21 receptor
• NCBI Official Symbol: IL21R
• NCBI Official Synonym Symbols: NILR; CD360; IMD56
• NCBI Protein Information: interleukin-21 receptor
• UniProt Protein Name: Interleukin-21 receptor
• Protein Family: Interleukin-21 receptor
• UniProt Gene Name: IL21R
• UniProt Synonym Gene Names: NILR; IL-21 receptor; IL-21R

NCBI Description

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]

Uniprot Description

This is a receptor for interleukin-21.