IL1RN recombinant protein

Recombinant Mouse IL1RN Protein

Cat. Num. AAA8249263

• Gene Names: Il1rn; IL-1ra; F630041P17Rik
• Reactivity: Mouse
• Applications: ELISA, Western Blot, SDS-Page
• Purity: Greater than 95% as determined by reducing SDS-PAGE.
• Synonyms: IL1RN; Recombinant Mouse IL1RN Protein; IL1F3; IL1RA; Interleukin-1 receptor antagonist protein; IL-1RN; IL-1ra; IRAP; ICIL-1RA; IL1 inhibitor; Anakinra; IL1RN recombinant protein

• Host: E Coli
• Reactivity: Mouse
• Purity/Purification: Greater than 95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 muM filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
• Sequence: MRPSGKRPCK MQAFRIWDTN QKTFYLRNNQ LIAGYLQGPN IKLEEKIDMV PIDLHSVFLG IHGGKLCLSC AKSGDDIKLQ LEEVNITDLS KNKEEDKRFT FIRSEKGPTT SFESAACPGW FLCTTLEADR PVSLTNTPEE PLIVTKFYFQ EDQ
• Sequence Length: 178

• Applicable Applications for IL1RN recombinant protein: ELISA (EIA),Western Blot (WB), SDS-PAGE, Mass Spectrometry (MS)
• Endotoxin: Less than 0.1 ng/mug (1 IEU/mug) as determined by LAL test.
• Directions for Use: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 mug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Preparation and Storage: Lyophilized protein should be stored at -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at -20 degree C for 3 months.

Related Product Information for IL1RN recombinant protein

Recombinant Mouse IL1RN Protein is produced by our E Coli expression system and the target gene encoding Arg27-Gln178 is expressed.

NCBI and Uniprot Product Information

• NCBI GI #: 89257344
• NCBI GeneID: 16181
• NCBI Accession #: NP_001034790.1
• NCBI GenBank Nucleotide #: NM_001039701.3
• UniProt Accession #: P25085; O70207
• Molecular Weight: 17,996 Da
• NCBI Official Full Name: interleukin-1 receptor antagonist protein isoform 2
• NCBI Official Synonym Full Names: interleukin 1 receptor antagonist
• NCBI Official Symbol: Il1rn
• NCBI Official Synonym Symbols: IL-1ra; F630041P17Rik
• NCBI Protein Information: interleukin-1 receptor antagonist protein
• UniProt Protein Name: Interleukin-1 receptor antagonist protein
• Protein Family: Interleukin-1 receptor antagonist protein
• UniProt Gene Name: Il1rn
• UniProt Synonym Gene Names: Il-1ra; IL-1RN; IL-1ra; IRAP
• UniProt Entry Name: IL1RA_MOUSE

Uniprot Description

IL1RN: Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. The intracellular form of IL1RN is predominantly expressed in epithelial cells. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Secreted; Secreted, signal peptide; Vesicle

Cellular Component: extracellular region; extracellular space; vesicle

Molecular Function: cytokine activity; interleukin-1 receptor antagonist activity; interleukin-1 receptor binding; interleukin-1 Type I receptor antagonist activity; interleukin-1 Type II receptor antagonist activity; interleukin-1, Type I receptor binding; interleukin-1, Type II receptor binding

Biological Process: cytokine and chemokine mediated signaling pathway; fever; insulin secretion; lipid metabolic process; memory; negative regulation of apoptosis; negative regulation of cell migration; negative regulation of glutamate secretion; negative regulation of heterotypic cell-cell adhesion; negative regulation of membrane potential; positive regulation of JNK activity; response to glucocorticoid stimulus; sensory perception of pain