IL-1R8 / IL1RAPL1 recombinant protein

Recombinant Mouse IL-1R8 / IL1RAPL1 Protein (Fc tag)

Cat. Num. AAA2546750

• Purity: > 95 % as determined by SDS-PAGE
• Synonyms: IL-1R8 / IL1RAPL1; Recombinant Mouse IL-1R8 / IL1RAPL1 Protein (Fc tag); RP23-301L16.1; 6330532G10Rik; C030039N24; IL1R8; IL1RAPL; MRX34; OPHN4; TIGIRR-2; IL-1R8 / IL1RAPL1 recombinant protein

• Host: Human Cells
• Purity/Purification: > 95 % as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH 7.4
• Sequence Length: 695

• Application Notes: The secreted recombinant mouse IL1RAPL1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 574 amino acids and has a calculated molecular mass of 65 kDa. As a result of glycosylation, the apparent molecular mass of rmIL1RAPL1/Fc monomer is approximately 85-95 kDa in SDS-PAGE under reducing conditions.
• Predicted N Terminal: Arg 25
• Endotoxin: < 1.0 EU per mug of the protein as determined by the LAL method
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -70 degree C

SDS-PAGE

Related Product Information for IL-1R8 / IL1RAPL1 recombinant protein

Background: Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1) is a member of interleukin-1 receptor family. The protein structurally comprises three extracellular immunoglobulin domains, which presumably mediate binding of an as yet unidentified ligand, a transmembrane region, and an intracellular domain, which is likely to enable signalling via the NFkB pathway. The means of signalling is almost certain to be identical to that used by the IL1R family and the more distally related Toll protein. L1RAPL1 protein physically interacts via its 150 aa C-terminal domain with neuronal calcium sensor-1 (NCS-1), a protein widely expressed in neurons and the related chromaffin and PC12 cells. IL1RAPL1 is an integral membrane protein responsible for a nonsyndromic form of mental retardation (MR). It is suggested to affect human cognitive ability to some extent, especially the memory and concentration capability.

Description: A DNA sequence encoding the mouse IL1RAPL1 (P59823) extracellular domain (Met 1-Thr 357) was fused with the Fc region of human IgG1 at the C-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 34222506
• UniProt Accession #: P59823
• Molecular Weight: 79,630 Da
• NCBI Official Full Name: Interleukin-1 receptor accessory protein-like 1
• UniProt Protein Name: Interleukin-1 receptor accessory protein-like 1
• UniProt Gene Name: Il1rapl1
• UniProt Synonym Gene Names: IL-1-RAPL-1; IL-1RAPL-1; IL1RAPL-1

Uniprot Description

IL1RAPL1: May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons. Defects in IL1RAPL1 are the cause of mental retardation X-linked type 21 (MRX21). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs. Belongs to the interleukin-1 receptor family. 1 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: X|X C1

Cellular Component: cell surface; dendrite; plasma membrane

Molecular Function: protein binding; receptor binding; voltage-gated calcium channel activity

Biological Process: heterophilic cell adhesion; negative regulation of exocytosis; neuron differentiation; positive regulation of dendrite morphogenesis