Human Interleukin-1 ELISA Kit | IL1RAPL1 elisa kit

Human Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1) ELISA Kit

Cat. Num. AAA283828

• Gene Names: IL1RAPL1; IL1R8; MRX10; MRX21; MRX34; OPHN4; IL1RAPL; TIGIRR-2; IL1RAPL-1; IL-1RAPL-1; IL-1-RAPL-1
• Reactivity: Human
• Synonyms: Interleukin-1; Human Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1) ELISA Kit; IL1R8; IL1RAPL; MRX10; MRX21; MRX34; OPHN4; TIGIRR-2; OTTHUMP00000023097|X-linked interleukin-1 receptor accessory protein-like 1|interleukin 1 receptor-8|mental retardation; X-linked 10|oligophreni; IL1RAPL1 elisa kit

• Reactivity: Human
• Specificity: This assay has high sensitivity and excellent specificity for detection of Human IL1RAPL1. No significant cross-reactivity or interference between Human IL1RAPL1 and analogues was observed.
• Sequence Length: 152

• Samples: Serum, Plasma, Other biological fluids
• Assay Type: Sandwich
• Sample Volume: 1-200 uL
• Precision: Intra-assay Precision (Precision within an assay); Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.; Inter-assay Precision (Precision between assays); Three samples of known concentration were tested in forty separate assays to assess inter-assay precision.; CV (%) = SD/meanX100; Intra-Assay: CV; Inter-Assay: CV
• Detection Wavelength: 450 nm
• Preparation and Storage: Store at 2-8 degree C.

Related Product Information for IL1RAPL1 elisa kit

Principle of the Assay: This assay employs a two-site sandwich ELISA to quantitate IL1RAPL1 in samples. An antibody specific for IL1RAPL1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyIL1RAPL1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for IL1RAPL1 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of IL1RAPL1 bound in the initial step. The color development is stopped and the intensity of the color is measured.

NCBI and Uniprot Product Information

• NCBI GI #: 7657232
• NCBI GeneID: 11141
• NCBI Accession #: NP_055086.1
• NCBI GenBank Nucleotide #: NM_014271.3
• UniProt Accession #: Q9NZN1; Q9UJ53; A0AVG4
• Molecular Weight: 79,969 Da
• NCBI Official Full Name: interleukin-1 receptor accessory protein-like 1
• NCBI Official Synonym Full Names: interleukin 1 receptor accessory protein like 1
• NCBI Official Symbol: IL1RAPL1
• NCBI Official Synonym Symbols: IL1R8; MRX10; MRX21; MRX34; OPHN4; IL1RAPL; TIGIRR-2; IL1RAPL-1; IL-1RAPL-1; IL-1-RAPL-1
• NCBI Protein Information: interleukin-1 receptor accessory protein-like 1
• UniProt Protein Name: Interleukin-1 receptor accessory protein-like 1
• Protein Family: Interleukin
• UniProt Gene Name: IL1RAPL1
• UniProt Synonym Gene Names: OPHN4; IL-1-RAPL-1; IL-1RAPL-1; IL1RAPL-1; TIGIRR-2

NCBI Description

The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. This protein has an N-terminal signal peptide, three extracellular immunoglobulin Ig-like domains, a transmembrane domain, an intracellular Toll/IL-1R domain, and a long C-terminal tail which interacts with multiple signalling molecules. This gene is located at a region on chromosome X that is associated with a non-syndromic form of X-linked intellectual disability. Deletions and mutations in this gene were found in patients with intellectual disability. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities, and plays a role in synapse formation and stabilization. [provided by RefSeq, Jul 2017]

Uniprot Description

IL1RAPL1: May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons. Defects in IL1RAPL1 are the cause of mental retardation X-linked type 21 (MRX21). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs. Belongs to the interleukin-1 receptor family. 1 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: Xp21.3-p21.2

Cellular Component: axon; cell surface; cytoplasm; dendrite; integral component of membrane; plasma membrane; postsynaptic membrane

Molecular Function: interleukin-1 binding; protein binding; receptor binding; voltage-gated calcium channel activity

Biological Process: heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; negative regulation of exocytosis; neuron differentiation; positive regulation of dendrite morphogenesis; positive regulation of synaptogenesis; signal transduction

Disease: Mental Retardation, X-linked 21