Il12a &Il12b heterodimer Recombinant Protein | Il12a recombinant protein

Recombinant Mouse Il12a &Il12b heterodimer protein, C-His Tag & C-TwinStrep tag

Cat. Num. AAA1560043

• Purity: >90% as determined by SDS-PAGE
• Synonyms: Il12a &Il12b heterodimer; Recombinant Mouse Il12a &Il12b heterodimer protein; C-His Tag & C-TwinStrep tag; Il12a recombinant protein

• Host: Mammalian
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Species: Mouse
• Reconstitution: Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details
• Construction: A DNA sequence encoding the mouse Il12a (Met1-Ala215) was fused with the C-terminal His Tag.; A DNA sequence encoding the mouse Il12b (Met1-Ser335) was fused with the C-terminal Twin-Strep tag.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; Shipping: In general, proteins are provided as lyophilized powder/frozen liquid.

SDS-Page

Product Categories/Family for Il12a recombinant protein

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NCBI and Uniprot Product Information

• NCBI GI #: 226874945
• NCBI GeneID: 16159
• NCBI Accession #: NP_001152896.1
• NCBI GenBank Nucleotide #: NM_001159424.1
• UniProt Accession #: P43431; P43432
• Molecular Weight: 24,179 Da
• NCBI Official Full Name: interleukin-12 subunit alpha isoform 1
• UniProt Protein Name: Interleukin-12 subunit alpha
• Protein Family: Interleukin
• UniProt Gene Name: Il12a
• UniProt Synonym Gene Names: IL-12A; CLMF p35
• UniProt Entry Name: IL12A_MOUSE

Uniprot Description

IL12A: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine- activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-6 superfamily.

Protein type: Secreted, signal peptide; Cytokine; Secreted

Cellular Component: extracellular space; interleukin-12 complex; cytoplasm; extracellular region

Molecular Function: interleukin-27 binding; growth factor activity; interleukin-12 beta subunit binding; protein heterodimerization activity; cytokine activity; interleukin-12 receptor binding

Biological Process: positive regulation of NK T cell activation; cell migration; positive regulation of cell adhesion; negative regulation of smooth muscle cell proliferation; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; positive regulation of T cell mediated cytotoxicity; positive regulation of tyrosine phosphorylation of Stat4 protein; response to lipopolysaccharide; defense response to protozoan; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of natural killer cell activation; response to UV-B; positive regulation of interferon-gamma production; negative regulation of interleukin-17 production; positive regulation of mononuclear cell proliferation; positive regulation of T cell differentiation; positive regulation of lymphocyte proliferation; positive regulation of T cell proliferation; immune response; cell cycle arrest