Mouse inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon ELISA Kit | IKBKE elisa kit

Mouse Inhibitor of nuclear factor kappa-B kinase subunit epsilon, IKBKE ELISA Kit

Cat. Num. AAA9322588

• Gene Names: Ikbke; Ikki; IKK-i; AW558201; IKKepsilon
• Reactivity: Mouse
• Synonyms: inhibitor of kappa light polypeptide gene enhancer in B-cells; kinase epsilon; Mouse Inhibitor of nuclear factor kappa-B kinase subunit epsilon; IKBKE ELISA Kit; Mouse Inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE) ELISA kit; RP11-534L20.1; IKK-i; IKKE; IKKI; KIAA0151; MGC125294; MGC125295; MGC125297; IKK-related kinase epsilon; inducible IkappaB kinase; IKBKE elisa kit

• Reactivity: Mouse
• Specificity: No significant cross-reactivity or interference between this analyte and analogues is observed.
• Sequence Length: 717

• Samples: Serum, Plasma and Tissue Homogenate
• Assay Type: Sandwich
• Detection Range: 1.2 pg/ml - 1000 pg/ml.
• Sensitivity: 5.0 pg/ml.
• Intra-assay Precision: Intra-assay CV (%) is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for IKBKE elisa kit

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only! This kit is intended to be used for determination the level of IKBKE (hereafter termed this analyte) in undiluted original Mouse serum, plasma and tissue homogenate samples.

NCBI and Uniprot Product Information

• NCBI GI #: 31981053
• NCBI GeneID: 56489
• NCBI Accession #: NP_062751.2
• NCBI GenBank Nucleotide #: NM_019777.3
• UniProt Accession #: Q9R0T8; Q8C2I3
• Molecular Weight: 80,953 Da
• NCBI Official Full Name: inhibitor of nuclear factor kappa-B kinase subunit epsilon
• NCBI Official Synonym Full Names: inhibitor of kappaB kinase epsilon
• NCBI Official Symbol: Ikbke
• NCBI Official Synonym Symbols: Ikki; IKK-i; AW558201; IKKepsilon
• NCBI Protein Information: inhibitor of nuclear factor kappa-B kinase subunit epsilon
• UniProt Protein Name: Inhibitor of nuclear factor kappa-B kinase subunit epsilon
• Protein Family: Inhibitor of nuclear factor kappa-B kinase
• UniProt Gene Name: Ikbke
• UniProt Synonym Gene Names: Ikke; Ikki; I-kappa-B kinase epsilon; IKK-E; IKK-epsilon; IkBKE; IKK-i
• UniProt Entry Name: IKKE_MOUSE

Uniprot Description

IKKE: a oncogenic kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Plays a pivotal role in coordinating the activation of IRF3 and NF-kappaB in the innate immune response. Its redistribution to PML nuclear bodies upon DNA damage is TOPORS-dependent. Is a breast cancer oncogene that exerts its oncogenic properties through cRel.

Protein type: Kinase, protein; EC 2.7.11.10; Inhibitor; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Other group; IKK family

Cellular Component: nucleoplasm; PML body; mitochondrial membrane; cytoplasm; nucleus

Molecular Function: NF-kappaB-inducing kinase activity; transferase activity; protein serine/threonine kinase activity; protein binding; IkappaB kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; ATP binding; protein kinase activity

Biological Process: DNA damage response, signal transduction resulting in induction of apoptosis; I-kappaB phosphorylation; response to DNA damage stimulus; phosphorylation; protein amino acid phosphorylation