IL-28B Recombinant Protein | IL28B recombinant protein

Human IL-28B Recombinant

Cat. Num. AAA553331

• Purity: >97%, as determined by SDS-PAGE
• Synonyms: IL-28B; Human IL-28B Recombinant; il-28; il28; IFNL3; IFNL4; IL28C; ZCYTO22; IL28B recombinant protein

• Host: HEK Cells
• Purity/Purification: >97%, as determined by SDS-PAGE
• Form/Format: Recombinant Human Interleukin-28B was lyophilized from a 0.2 um filtered PBS solution pH 7.4.
• Sequence Length: 196

• Host Note: DNA sequence encoding mature chain of Human IL28B to a C-terminal polyHis tag was expressed in HEK cells.
• Endotoxin: Endotoxin content was assayed using a LAL gel clot method.; Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
• Reconstitution: A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
• Molecular Weight Note: Recombinant Human Interleukin-28B (Interferon lambda) is a monomer consisting of 186 amino acid residue, and migrates as an approximately 23 kDa protein under reducing conditions in SDS-PAGE.
• Preparation and Storage: The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C.; Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity. ; ; Avoid repeated freeze/thaw cycles.

Related Product Information for IL28B recombinant protein

Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.

Product Categories/Family for IL28B recombinant protein

Cytokines

References

• association between the IL28B genotype and hepatitis c viral kinetics in the early days of treatment with pegylated interferon plus ribavirin in hiv/hcv co-infected patients with genotype 1 or 4 .J. Antimicrob. Chemother., Jan 2012; 67: 202 - 205.
• IL28B rs12979860 genotype and spontaneous clearance of hepatitis c virus in a multi-ethnic cohort of injection drug users: evidence for a supra-additive association .The Journal of Infectious Disease, Dec 2011; 204: 1843 - 1847.
• predictors of sustained virological response after antiviral therapy for chronic hepatitis c in patients with hemophilia: the role of the interleukin-28b (IL28B) polymorphism .Blood (ASH Annual Meeting Abstracts), Nov 2011; 118: 2276.
• genetic polymorphism in IL28B is associated with spontaneous clearance of hepatitis c virus genotype 4 infection in an egyptian cohort .The Journal of Infectious Disease, Nov 2011; 204: 1391 - 1394.
• genetic polymorphism in IL28B is associated with spontaneous clearance of hepatitis c virus genotype 4 infection in an egyptian cohort .The Journal of Infectious Disease, Nov 2011; 204: 1391 - 1394.