Typical Testing Data/Standard Curve (for reference only)
Human Hyaluronidase-1 ELISA Kit | HYAL1 elisa kit
Human Hyaluronidase-1 ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
HYAL1: May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. Defects in HYAL1 are the cause of mucopolysaccharidosis type 9 (MPS9); also called hyaluronidase deficiency. MPS9 is a lysosomal storage disease characterized by high hyaluronan (HA) concentration in the serum. The clinical features are periarticular soft tissue masses, mild short stature and acetabular erosions, and absence of neurological or visceral involvement. Belongs to the glycosyl hydrolase 56 family. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.2.1.35; Glycan Metabolism - glycosaminoglycan degradation; Hydrolase; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component: cytoplasm; cytoplasmic vesicle; extracellular space; lysosomal lumen; lysosome
Molecular Function: hyaluronan synthase activity; hyalurononglucosaminidase activity; transcription factor binding; viral receptor activity
Biological Process: cartilage development; chondroitin sulfate catabolic process; hyaluronan biosynthetic process; hyaluronan catabolic process; hyaluronan metabolic process; inflammatory response; negative regulation of cell growth; positive regulation of angiogenesis; positive regulation of cell adhesion; positive regulation of cell growth; positive regulation of epithelial cell proliferation; positive regulation of growth; response to antibiotic; response to reactive oxygen species; response to virus
Disease: Mucopolysaccharidosis, Type Ix
Research Articles on HYAL1
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Product Notes
The Human HYAL1 hyal1 (Catalog #AAA2887734) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2887734 ELISA Kit recognizes Human HYAL1. It is sometimes possible for the material contained within the vial of "Hyaluronidase-1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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