Immunohistochemistry (IHC)
( Immunohistochemical staining of rat spleen tissue using anti-CD11a antibody hu1124 (Efalizumab). Anti-CD11a staining of formaldehyde fixed paraffin embedded rat spleen tissue, at 40x magnification. The human IgG1-chimeric version of hu1124 was used to stain samples at a concentration of 3 ug/ml.)
CD11a recombinant antibody
Anti-CD11a [hu1124 (Efalizumab)]
Reactivity
Human
Applications
Flow Cytometry, Functional Assay
Purity
Protein A Affinity Purified
Synonyms
CD11a; Anti-CD11a [hu1124 (Efalizumab)]; LFA-1; integrin alpha L; CD11a recombinant antibody
Reactivity
Human
Isotype
Human IgG1, kappa
Clone Number
hu1124 (Efalizumab)
Specificity
Binds to human LFA-1.
Purity/Purification
Protein A Affinity Purified
Applicable Applications for CD11a recombinant antibody
Block, Flow Cytometry (FC/FACS)
Application Notes
Efalizumab binds to the LFA-1 alpha I domain blocking the ICAM-1 binding site via steric hindrance.
Buffer Composition
PBS only with 0.02% Proclin 300.
Immunogen
Efalizumab binds to CD11a, a subunit of leukocyte function antigen-1 (LFA-1), which is expressed on all leukocytes.
Preparation and Storage
Store at 4 degree C for up to 3 months. For longer storage, aliquot and store at -20 degree C.
Immunohistochemistry (IHC)
( Immunohistochemical staining of rat spleen tissue using anti-CD11a antibody hu1124 (Efalizumab). Anti-CD11a staining of formaldehyde fixed paraffin embedded rat spleen tissue, at 40x magnification. The human IgG1-chimeric version of hu1124 was used to stain samples at a concentration of 3 ug/ml.)
Immunohistochemistry (IHC)
( Immunohistochemical staining of rat spleen tissue using anti-CD11a antibody hu1124 (Efalizumab). Anti-CD11a staining of formaldehyde fixed paraffin embedded rat spleen tissue, at 40x magnification. The human IgG1-chimeric version of hu1124 was used to stain samples at a concentration of 3 ug/ml.)
Related Product Information for CD11a recombinant antibody
Recombinant monoclonal antibody to CD11a. Manufactured using a Recombinant Platform with variable regions (i.e. specificity) from the therapeutic antibody hu1124 (Efalizumab).
Product Categories/Family for CD11a recombinant antibody
References
Bauer et al. Population pharmacokinetics and pharmacodynamics of the anti-CD11a antibody hu1124 in human subjects with psoriasis. J Pharmacokinet Biopharm. 1999 Aug; 27(4):397-420. PMID:10826130
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Product Notes
The CD11a (Catalog #AAA488210) is a Recombinant Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-CD11a [hu1124 (Efalizumab)] reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD11a can be used in a range of immunoassay formats including, but not limited to, Block, Flow Cytometry (FC/FACS). Efalizumab binds to the LFA-1 alpha I domain blocking the ICAM-1 binding site via steric hindrance. Researchers should empirically determine the suitability of the CD11a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD11a, Recombinant Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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