Fibronectin Protein | fn1 protein
Fibronectin, Human
Fibronectin is isolated from human plasma by thermal precipitation, ion exchange, and gelatin-agarose affinity chromatography. Purity is assessed by SDS-PAGE analysis.
Fibronectin is isolated from human plasma by thermal precipitation, ion exchange, and gelatin-agarose affinity chromatography. Purity is assessed by SDS-PAGE analysis.
The apparent function of fibronectin is to mediate cell attachment by interacting with cell surface receptors and extracellular matrix components (10-12). Fibronectin contains an Arg-Gly-Asp-Ser (RGDS) cell attachment-promoting sequence within one of the type-III homology segments in the middle of the molecule (13). This RGDS site is recognized by specific RGDS-dependent cell receptors (13) which are members of the integrin family of proteins (14). Fibronectin binding to activated platelets (15) is mediated through the RGDS cell adhesion sequence (16). Other binding domains specific for such extracellular macromolecules as heparin, fibrin(ogen), and collagen (10-12) have been identified and may be important in the fibronectin-mediated adhesion of platelets to the extracellular matrix of endothelial cells (17). Fibrin-fibronectin complexes are stabilized by the factor XIIIa-catalyzed covalent cross-linking of fibronectin to the a chain of fibrin (18).
NCBI and Uniprot Product Information
Uniprot Description
Function: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. May be involved in osteoblast compaction
By similarity.
Subunit structure: Dimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends
By similarity.
Tissue specificity: In early Xenopus embryo, cellular forms of fibronectin predominate which include both extra domains. In fibronectin of embryonic and adult liver the connecting strand 3 can be either completely excluded or included.
Post-translational modification: Forms covalent cross-links mediated by a transglutaminase, such as F13A or TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers (e.g. fibrinogen-fibronectin, collagen-fibronectin heteropolymers).
Sequence similarities: Contains 12 fibronectin type-I domains.Contains 2 fibronectin type-II domains.Contains 17 fibronectin type-III domains.
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Product Notes
The fn1 fn1 (Catalog #AAA635084) is a Protein produced from Human plasma and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Fibronectin, Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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