Alpha-1 Antichymotrypsin Protein | ACT protein
Alpha-1 Antichymotrypsin (A1AT), Human Serum (Alpha 1-ACT)
Centrifuge briefly to ensure complete recovery. Prepare further dilutions in the lyophilization buffer.
-20°C
Protect from moisture
Custom preparations, technical support, bulk quantities and aliquoting available.
Human Alpha 1 antichymotrypsin is an alpha globulin glycoprotein and serpin. This Human Glycoprotein is found in alpha(1)-globulin region in human serum. Human Alpha 1-antichymotrypsin (ACT) (Alpha 1-ACT) inhibits chymotrypsin-like proteinases in vivo and has cytotoxic killer-cell activity in vitro and also has a role as an acute-phase protein and is active in the control of immunologic and inflammatory processes, and as a tumor marker. Human ACT is a member of the serpin superfamily.
Human Alpha 1-Antichymotrypsin (Alpha 1-ACT) (ACT)can complex with human PSA to form human PSA-ACT complex which is used as an indicator of tumour mass and clinical stage of prostate cancer.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq, Jul 2008]
Uniprot Description
SERPINA3: Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 14q32.1
Cellular Component: extracellular space; extracellular region; intracellular; nucleus
Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; DNA binding
Biological Process: regulation of lipid metabolic process; maintenance of gastrointestinal epithelium; acute-phase response; inflammatory response
Research Articles on ACT
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Product Notes
The ACT serpina3 (Catalog #AAA173007) is a Protein produced from Human plasma and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Alpha-1 Antichymotrypsin, Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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