Factor IX Native Protein | F9 native protein

Factor IX protein

Cat. Num. AAA537154

• Gene Names: F9; FIX; P19; PTC; HEMB; THPH8
• Applications: User optimized
• Purity: > 95% pure
• Synonyms: Factor IX; Factor IX protein; Complement Factor IX; F9 native protein

• Host: Human
• Purity/Purification: > 95% pure
• Form/Format: 20mM Tris-HCL, 0.1M NaCl, 1mM Benzamidine pH 7.4.
• Sequence Length: 462

• Applicable Applications for F9 native protein: User optimized
• Source Note: Human plasma
• Protein Type: Native
• Biological Significance: Factor IX is a vitamin K-dependent glycoprotein produced in the liver. Plasma concentration of F.IX is normally around 5 ug/ml (87 nM) in plasma. The biological importance of F.IX is demonstrated in Haemophilia B an X-linked congenital bleeding disease resulting from a quantitative or qualitative defect in F.IX function.
• Biohazard Information: Donor samples were tested and found to be negative for Anti-HIV1/2, Anti-HTLV I & II, HBsAg, Anti-HCV, Syphilis, HBC Ab, HIV-1 p24 Ag or HIV-1 RNA, HCV RNA and HBV RNA. Nonetheless caution should be used when handling this material as there is a margin of error in all tests. Donors were also screened for CJD (Creutzfeldt-Jakob Disease).
• Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
• Additional Remarks: Activity: 306.5 PEU/ mg; 1PEU is equal to the amount of activity found in 1ml of plasma as determined in factor deficient; clotting assay.; MBS537154; 219ul; 0.5mg; 153.25 PEU (Units); (Lot Specific)
• Preparation and Storage: Aliquot and store at -70 degree C or lower. Avoid repeated freeze/thaw cycles; Shipping: Ships with Dry Ice.

Related Product Information for F9 native protein

Purified native Human Factor IX protein

Product Categories/Family for F9 native protein

Proteases; Inhibitors; & Enzymes; Native Protein

NCBI and Uniprot Product Information

• NCBI GI #: 182609
• NCBI GeneID: 2158
• UniProt Accession #: P00740; Q5FBE1; Q5JYJ8; A8K9N4; F2RM36
• Molecular Weight: 56 kDa
• NCBI Official Full Name: factor IX
• NCBI Official Synonym Full Names: coagulation factor IX
• NCBI Official Symbol: F9
• NCBI Official Synonym Symbols: FIX; P19; PTC; HEMB; THPH8
• NCBI Protein Information: coagulation factor IX
• UniProt Protein Name: Coagulation factor IX
• Protein Family: Coagulation factor
• UniProt Gene Name: F9
• UniProt Synonym Gene Names: PTC
• UniProt Entry Name: FA9_HUMAN

NCBI Description

This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. [provided by RefSeq, Jul 2008]

Uniprot Description

F9: Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. Defects in F9 are the cause of recessive X-linked hemophilia B (HEMB); also known as Christmas disease. Mutations in position 43 (Oxford-3, San Dimas) and 46 (Cambridge) prevents cleavage of the propeptide, mutation in position 93 (Alabama) probably fails to bind to cell membranes, mutation in position 191 (Chapel-Hill) or in position 226 (Nagoya OR Hilo) prevent cleavage of the activation peptide. Defects in F9 are the cause of thrombophilia due to factor IX defect (THPH8). A hemostatic disorder characterized by a tendency to thrombosis. Belongs to the peptidase S1 family.

Protein type: Secreted; Protease; Secreted, signal peptide; EC 3.4.21.22

Chromosomal Location of Human Ortholog: Xq27.1-q27.2

Cellular Component: endoplasmic reticulum lumen; Golgi lumen; extracellular region; plasma membrane

Molecular Function: serine-type endopeptidase activity; calcium ion binding

Biological Process: blood coagulation, extrinsic pathway; cellular protein metabolic process; proteolysis; blood coagulation; post-translational protein modification; blood coagulation, intrinsic pathway; peptidyl-glutamic acid carboxylation

Disease: Hemophilia B; Thrombophilia, X-linked, Due To Factor Ix Defect; Coumarin Resistance