Testing Data

IgA1, Human Myeloma Plasma Immunoglobulin | IGHA1 immunoglobulin

IgA1, Human Myeloma Plasma

Gene Names

IGHA1; IgA1

Purity

Greater than 955 by SDS-PAGE

Synonyms

IgA1; Human Myeloma Plasma; IGHA1 immunoglobulin

Ordering
Cat. Num. AAA135562 For Research Use Only!

Host

Human myeloma plasma

Isotype

IgA1 kappa

Purity/Purification

Greater than 955 by SDS-PAGE

Form/Format

3.32 ml 10mM Na Phosphate, pH 7.4, with 150 mM NaCI and 0.05% sodium azide.

Concentration

Protein Concentration: 3.01 mg/mL (varies by lot)

Sequence Length

353

Preparation and Storage

Ships on dry ice. Store at -20°C.

Testing Data

Related Product Information for IGHA1 immunoglobulin

In normal adult serum, the approximate percentage composition of IgA with respect to is subclasses is IgA1: 90% and IgA2: 10%. In secretory IgA, the subclass proportions may approach 50:50. The clinical significance of the subclasses has yet to be determined. No reaction by IEP to IgA2 antiserum. Prepared from myeloma plasma shown to be non reactive for HbsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests. >95% pure by SDS-PAGE.

Product Categories/Family for IGHA1 immunoglobulin

Human Immunoglobulins; Human Immunoglobulins

NCBI and Uniprot Product Information

NCBI GI #

113584

NCBI GeneID

3493

UniProt Accession #

P01876

NCBI Official Full Name

Ig alpha-1 chain C region

NCBI Official Synonym Full Names

immunoglobulin heavy constant alpha 1

NCBI Official Symbol

IGHA1

NCBI Official Synonym Symbols

IgA1

UniProt Protein Name

Ig alpha-1 chain C region

Protein Family

Ig alpha-1 chain C region

UniProt Gene Name

IGHA1

UniProt Entry Name

IGHA1_HUMAN

Uniprot Description

IGHA1: Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system. A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.

Protein type: Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 14q32.33

Cellular Component: extracellular space; extracellular region

Molecular Function: antigen binding

Biological Process: retinal homeostasis; receptor-mediated endocytosis; glomerular filtration; antibacterial humoral response; immune response; protein-chromophore linkage

Research Articles on IGHA1

1. In breast cancer, elevated levels of antibodies recognizing aberrant MUC1 are associated with better outcome, whereas in IgA nephropathy, the antibodies recognizing aberrant IgA1 are part of the pathogenetic process. [review]

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Product Notes

The IGHA1 igha1 (Catalog #AAA135562) is an Immunoglobulin produced from Human myeloma plasma and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "IgA1, Human Myeloma Plasma, Immunoglobulin" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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IgA1, Human Myeloma Plasma Immunoglobulin | IGHA1 immunoglobulin