POLR2G blocking peptide

POLR2G Immunizing Peptide

Cat. Num. AAA426961

• Gene Names: POLR2G; RPB7; RPB19; hRPB19; hsRPB7
• Reactivity: Human, Mouse, Rat, Sheep
• Synonyms: POLR2G; POLR2G Immunizing Peptide; polymerase (RNA) II (DNA directed) polypeptide G; MGC138367; MGC138369; RPB7; hRPB19; hsRPB7; DNA directed RNA polymerase II 19 kda polypeptide; DNA directed RNA polymerase II polypeptide G; RNA polymerase II seventh subunit; POLR2G blocking peptide

• Reactivity: Human, Mouse, Rat, Sheep
• Form/Format: 100ug of dried peptide
• Sequence: EFDPNSNPPCYK
• Sequence Length: 172

• Preparation and Storage: Shipped at ambient temperature, store at -20 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 4505947
• NCBI GeneID: 5436
• NCBI Accession #: NP_002687.1
• NCBI GenBank Nucleotide #: NM_002696.2
• Molecular Weight: 19,294 Da
• NCBI Official Full Name: DNA-directed RNA polymerase II subunit RPB7
• NCBI Official Synonym Full Names: polymerase (RNA) II subunit G
• NCBI Official Symbol: POLR2G
• NCBI Official Synonym Symbols: RPB7; RPB19; hRPB19; hsRPB7
• NCBI Protein Information: DNA-directed RNA polymerase II subunit RPB7
• UniProt Protein Name: DNA-directed RNA polymerase II subunit RPB7
• UniProt Gene Name: POLR2G
• UniProt Synonym Gene Names: RPB7; RNA polymerase II subunit B7; RPB19
• UniProt Entry Name: RPB7_HUMAN

NCBI Description

This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The protein functions in transcription initiation, and is also thought to help stabilize transcribing polyermase molecules during elongation. [provided by RefSeq, Jan 2009]

Uniprot Description

POLR2G: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA. Binds RNA. Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.

Protein type: Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: DNA-directed RNA polymerase II, core complex; nucleoplasm; nucleus

Molecular Function: DNA-directed RNA polymerase activity; single-stranded DNA binding; single-stranded RNA binding; translation initiation factor binding

Biological Process: apoptosis; fibroblast growth factor receptor signaling pathway; gene expression; mRNA capping; mRNA catabolic process, exonucleolytic; nuclear mRNA splicing, via spliceosome; positive regulation of translational initiation; positive regulation of viral transcription; RNA elongation from RNA polymerase II promoter; RNA-mediated gene silencing; snRNA transcription from RNA polymerase II promoter; somatic stem cell maintenance; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair