Testing Data
(The TFact STAT1 DNA-Binding ELISA detects active STAT1 in Hela and HepG2 Nuclear Extract. The Hela and HepG2 cells were grown 3 days in DMEM with 10% FBS and harvested for nuclear extract. The Hela cells were stimulated by PMA (200nM) before harvest.)
STAT1 elisa kit
STAT1 TFact DNA-Binding ELISA Kit
Testing Data
(The TFact STAT1 DNA-Binding ELISA detects active STAT1 in Hela and HepG2 Nuclear Extract. The Hela and HepG2 cells were grown 3 days in DMEM with 10% FBS and harvested for nuclear extract. The Hela cells were stimulated by PMA (200nM) before harvest.)
Testing Data
(The TFact STAT1 DNA-Binding ELISA detects active STAT1 in Hela and HepG2 Nuclear Extract. The Hela and HepG2 cells were grown 3 days in DMEM with 10% FBS and harvested for nuclear extract. The Hela cells were stimulated by PMA (200nM) before harvest.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Description
STAT1: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of certain receptor tyrosine kinases, GPCRs, and receptors for various interleukins and interferons. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 2q32.2
Cellular Component: axon; cytoplasm; cytosol; dendrite; nuclear chromatin; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; protein complex
Molecular Function: cadherin binding; CCR5 chemokine receptor binding; DNA binding transcription factor activity; double-stranded DNA binding; enzyme binding; histone acetyltransferase binding; histone binding; identical protein binding; nuclear hormone receptor binding; promoter-specific chromatin binding; protein binding; protein homodimerization activity; protein phosphatase 2A binding; signal transducer activity; tumor necrosis factor receptor binding; ubiquitin-like protein ligase binding
Biological Process: apoptosis; blood circulation; cellular response to insulin stimulus; cellular response to interferon-gamma; cellular response to organic cyclic compound; defense response to virus; endothelial cell migration; JAK-STAT cascade; macrophage derived foam cell differentiation; metanephric mesenchymal cell differentiation; metanephric mesenchymal cell proliferation involved in metanephros development; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; negative regulation of metanephric nephron tubule epithelial cell differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of viral protein levels in host cell; positive regulation of defense response to virus by host; positive regulation of erythrocyte differentiation; positive regulation of interferon-alpha production; positive regulation of mesenchymal cell proliferation; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; regulation of apoptosis; response to cAMP; response to cytokine; response to drug; response to hydrogen peroxide; response to mechanical stimulus; response to nutrient; response to peptide hormone; transcription, DNA-dependent; tumor necrosis factor-mediated signaling pathway; viral process
Disease: Immunodeficiency 31a; Immunodeficiency 31b; Immunodeficiency 31c
Research Articles on STAT1
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Product Notes
The Human, Mouse, Rat STAT1 stat1 (Catalog #AAA9502258) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9502258 ELISA Kit recognizes Human, Mouse, Rat STAT1. It is sometimes possible for the material contained within the vial of "STAT1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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