mGluR7 elisa kit
mGluR7 Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Uniprot Description
mGluR7: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. Belongs to the G-protein coupled receptor 3 family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 3p26.1
Cellular Component: asymmetric synapse; axon; cell cortex; dendrite; dendritic shaft; integral component of membrane; integral component of plasma membrane; plasma membrane; postsynaptic membrane; presynaptic active zone; presynaptic membrane; receptor complex
Molecular Function: adenylate cyclase inhibitor activity; calcium channel regulator activity; glutamate receptor activity; group III metabotropic glutamate receptor activity
Biological Process: behavioral fear response; G-protein coupled receptor signaling pathway; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway; negative regulation of cAMP biosynthetic process; negative regulation of glutamate secretion; regulation of cyclase activity; regulation of synaptic transmission, glutamatergic; sensory perception of sound; synaptic transmission
Research Articles on mGluR7
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Product Notes
The Human, Mouse, Rat mGluR7 grm7 (Catalog #AAA9500384) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9500384 ELISA Kit recognizes Human, Mouse, Rat mGluR7. It is sometimes possible for the material contained within the vial of "mGluR7, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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