C/EBP-alpha elisa kit
Phospho-C/EBP-alpha (Ser21) Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]
Uniprot Description
C/EBP-alpha: a bZIP transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 19q13.11
Cellular Component: intracellular membrane-bound organelle; nucleolus; nucleoplasm; nucleus; RNA polymerase II transcription factor complex
Molecular Function: DNA binding; DNA binding transcription factor activity; kinase binding; protein binding; protein homodimerization activity; transcription coactivator activity; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; transcription factor binding; transcription regulatory region DNA binding
Biological Process: brown fat cell differentiation; cell maturation; cellular response to lithium ion; cellular response to organic cyclic compound; cellular response to tumor necrosis factor; cholesterol metabolic process; cytokine-mediated signaling pathway; embryonic placenta development; fat cell differentiation; generation of precursor metabolites and energy; glucose homeostasis; granulocyte differentiation; inner ear development; lipid homeostasis; liver development; lung development; macrophage differentiation; mitochondrion organization; myeloid cell differentiation; negative regulation of cell proliferation; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; Notch signaling pathway; positive regulation of fat cell differentiation; positive regulation of osteoblast differentiation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase III promoter; transcription from RNA polymerase II promoter; transcription, DNA-dependent; urea cycle; viral process; white fat cell differentiation
Disease: Leukemia, Acute Myeloid
Research Articles on C/EBP-alpha
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Product Notes
The Human, Mouse, Rat C/EBP-alpha cebpa (Catalog #AAA9501008) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9501008 ELISA Kit recognizes Human, Mouse, Rat C/EBP-alpha. It is sometimes possible for the material contained within the vial of "C/EBP-alpha, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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