STK39 Antibody | anti-STK39 antibody

STK39 Antibody

Cat. Num. AAA855742

• Gene Names: STK39; DCHT; PASK; SPAK
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: STK39; STK39 Antibody; DCHT; EC 2.7.11.1; Serine/threonine-protein kinase 39; SPAK; Ste-20 related kinase; STE20/SPS1-related proline-alanine rich protein kinase; anti-STK39 antibody

• Reactivity: Human, Mouse, Rat
• Specificity: STK39 antibody detects endogenous levels of total STK39 protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 545

• Applicable Applications for anti-STK39 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500~1:1000; ELISA: 1:40000
• Immunogen: The antiserum was produced against synthesized peptide derived from internal of human STK39.
• Preparation and Storage: Store at-20 degree C for 1 year.

Testing Data #2

(Western blot analysis of extracts from COLO cells, using STK39 antibody.)

Product Categories/Family for anti-STK39 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

References

Johnston A.M., Oncogene 19:4290-4297(2000). Melnick M.B., Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases. Olsen J.V., Cell 127:635-648(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 115430252
• NCBI GeneID: 27347
• NCBI Accession #: NP_037365.2
• NCBI GenBank Nucleotide #: NM_013233.2
• UniProt Accession #: Q9UEW8; O14774; Q53S90; Q53SL7; Q53SS1; Q9UER4; X5D9C8
• Molecular Weight: 57,937 Da
• NCBI Official Full Name: STE20/SPS1-related proline-alanine-rich protein kinase
• NCBI Official Synonym Full Names: serine/threonine kinase 39
• NCBI Official Symbol: STK39
• NCBI Official Synonym Symbols: DCHT; PASK; SPAK
• NCBI Protein Information: STE20/SPS1-related proline-alanine-rich protein kinase
• UniProt Protein Name: STE20/SPS1-related proline-alanine-rich protein kinase
• Protein Family: STE20/SPS1-related proline-alanine-rich protein kinase
• UniProt Gene Name: STK39
• UniProt Synonym Gene Names: SPAK; Ste-20-related kinase

NCBI Description

This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008]

Uniprot Description

May act as a mediator of stress-activated signals. Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation.