PSMD2 Antibody | anti-PSMD2 antibody

PSMD2 Antibody

Cat. Num. AAA858305

• Gene Names: PSMD2; S2; P97; RPN1; TRAP2
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: PSMD2; PSMD2 Antibody; 26S proteasome non-ATPase regulatory subunit 2; 26S proteasome regulatory subunit RPN1; 26S proteasome regulatory subunit S2; 26S proteasome subunit p97; 55.11 protein; TRAP2; Tumor necrosis factor type 1 receptor-associated protein 2; anti-PSMD2 antibody

• Reactivity: Human, Mouse, Rat
• Specificity: PSMD2 antibody detects endogenous levels of total PSMD2 protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 778

• Applicable Applications for anti-PSMD2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500~1:1000; ELISA: 1:20000
• Immunogen: The antiserum was produced against synthesized peptide derived from internal of human PSMD2.
• Preparation and Storage: Store at-20 degree C for 1 year.

Western Blot (WB)

(Western blot analysis of extracts from COLO205 cells and 293 cells, using PSMD2 antibody.)

Product Categories/Family for anti-PSMD2 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

References

Tsurumi C., Eur. J. Biochem. 239:912-921(1996). Dunbar J.D., J. Immunol. 158:4252-4259(1997). Olsen J.V., Cell 127:635-648(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 523425734
• NCBI GeneID: 5708
• NCBI Accession #: NP_001265637.1
• NCBI GenBank Nucleotide #: NM_001278708.1
• UniProt Accession #: Q13200; Q12932; Q15321; Q53XQ4; Q96I12; B4DX07; B4DXY1; E7EW34; E9PCS3
• Molecular Weight: 85,606 Da
• NCBI Official Full Name: 26S proteasome non-ATPase regulatory subunit 2 isoform 2
• NCBI Official Synonym Full Names: proteasome 26S subunit, non-ATPase 2
• NCBI Official Symbol: PSMD2
• NCBI Official Synonym Symbols: S2; P97; RPN1; TRAP2
• NCBI Protein Information: 26S proteasome non-ATPase regulatory subunit 2
• UniProt Protein Name: 26S proteasome non-ATPase regulatory subunit 2
• Protein Family: 26S proteasome non-ATPase regulatory
• UniProt Gene Name: PSMD2
• UniProt Synonym Gene Names: TRAP2

NCBI Description

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Uniprot Description

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.