PP2A-alpha Antibody | anti-PP2A-alpha antibody

PP2A-alpha antibody

Cat. Num. AAA859032

• Gene Names: PPP2CA; RP-C; PP2Ac; PP2CA; PP2Calpha
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: PP2A-alpha; PP2A-alpha antibody; anti-PP2A-alpha antibody

• Reactivity: Human, Mouse, Rat
• Specificity: PP2A-alphaantibody detects endogenous levels of total PP2A-alphaprotein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 309

• Applicable Applications for anti-PP2A-alpha antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: The antiserum was produced against a synthesized peptide Corresponding to the amino terminal sequence from human PP2A-alphaprotein ("KQLSESQVKSL").
• Preparation and Storage: Store at-20 degree C for 1 year

Testing Data

(Western blot analysis of extracts from various cells using PP2A-alphaantibody (E021405, Lane 1, 2, 3, 4 and 5).)

Product Categories/Family for anti-PP2A-alpha antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

References

Yu, X.X. et al. (2001) Mol. Biol. Cell 12, 185-199. Tolstykh, T. et al. (2000) EMBO J. 19, 5682-5691. Janssens, V. and Goris, J. (2001) Biochem. J. 353, 417-439.

NCBI and Uniprot Product Information

• NCBI GI #: 4506017
• NCBI GeneID: 5515
• NCBI Accession #: NP_002706.1
• NCBI GenBank Nucleotide #: NM_002715.3
• UniProt Accession #: P67775; P05323; P13197
• Molecular Weight: 29,735 Da
• NCBI Official Full Name: serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform 1
• NCBI Official Synonym Full Names: protein phosphatase 2 catalytic subunit alpha
• NCBI Official Symbol: PPP2CA
• NCBI Official Synonym Symbols: RP-C; PP2Ac; PP2CA; PP2Calpha
• NCBI Protein Information: serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
• UniProt Protein Name: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
• UniProt Gene Name: PPP2CA
• UniProt Synonym Gene Names: PP2A-alpha; RP-C

NCBI Description

This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]

Uniprot Description

PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.