Sema-4D and Plexin B1 Receptor Antibody Sampler Kit | Sema-4D antibody sampler kit
Sema-4D and Plexin B1 Receptor
Reactivity
Human, Rat, Mouse
Applications
Western Blot, ELISA, Immunocytochemistry
Synonyms
Sema-4D and Plexin B1 Receptor; Sema-4D antibody sampler kit
Reactivity
Human, Rat, Mouse
Form/Format
Rabbit polyclonal and mouse monoclonal antibodies are supplied in phosphate-buffered saline (PBS), 50% glycerol, 1mg/ml BSA, and 0.05% sodium azide. The secondary reagents are supplied in the same buffer without azide, and thepeptide is supplied in PBS an
Applicable Applications for Sema-4D antibody sampler kit
Western Blot (WB), ELISA (EIA), Immunocytochemistry (ICC)
Preparation and Storage
Store all at -20 degree C. Stable for 1 year.
Related Product Information for Sema-4D antibody sampler kit
Kit Summary: The Sema-4D and Plexin B1 Receptor antibody sampler kit can be used to detect the changes in the expression ofSemaphorin 4D and its receptor Plexin B1. The kit also includes a Plexin B1 peptide for antibody blocking experimentsand secondary reagents for antibody detection.
Background: Plexins are a family of large integral membrane proteins that complex with neuropilins to form semaphorin co-receptors. The extracellular region of plexins contains a semaphorin domain, multiple glycine-rich motifs, and MET-relatedsequences. The cytoplasmic region contains a Sex/Plexin domain and putative tyrosine phosphorylation sites thatmediate signal transduction after activation. In addition to these motifs, the Plexin B1 and B2 family members containcleavage sites for subtilisin-like proprotein convertases. These cleavage sites may be important for regulating assemblyof heterodimeric receptors or release of the extracellular domain. Plexin-B1 is expressed as a 300kDa precursor proteinthat can be cleaved into a 200kDa a-subunit and a 100kDa b-subunit. This plexin is the receptor for the class IV semaphorin, Sema-4D. Sema-4D activation of Plexin B1 recruits and activates c-Met, which can promote cell survival, migration, and angiogenesis.
Background: Plexins are a family of large integral membrane proteins that complex with neuropilins to form semaphorin co-receptors. The extracellular region of plexins contains a semaphorin domain, multiple glycine-rich motifs, and MET-relatedsequences. The cytoplasmic region contains a Sex/Plexin domain and putative tyrosine phosphorylation sites thatmediate signal transduction after activation. In addition to these motifs, the Plexin B1 and B2 family members containcleavage sites for subtilisin-like proprotein convertases. These cleavage sites may be important for regulating assemblyof heterodimeric receptors or release of the extracellular domain. Plexin-B1 is expressed as a 300kDa precursor proteinthat can be cleaved into a 200kDa a-subunit and a 100kDa b-subunit. This plexin is the receptor for the class IV semaphorin, Sema-4D. Sema-4D activation of Plexin B1 recruits and activates c-Met, which can promote cell survival, migration, and angiogenesis.
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Product Notes
The Human, Rat, Mouse Sema-4D (Catalog #AAA474567) is an Antibody Sampler Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA474567 Antibody Sampler Kit recognizes Human, Rat, Mouse Sema-4D. AAA Biotech's Sema-4D and Plexin B1 Receptor can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunocytochemistry (ICC). Researchers should empirically determine the suitability of the Sema-4D for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Sema-4D and Plexin B1 Receptor, Antibody Sampler Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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