Girdin Phospho-Regulation Antibody Sampler Kit
Girdin Phospho-Regulation
Reactivity
Human, Rat, Mouse
Applications
Western Blot, ELISA, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation
Synonyms
Girdin Phospho-Regulation; GirdinK; Girdin Phospho-Regulation antibody sampler kit
Reactivity
Human, Rat, Mouse
Form/Format
Primary antibodies are supplied in phosphate-buffered saline, 50% glycerol, 1mg/ml BSA, and 0.05% sodium azide. The secondary reagents are supplied in the same buffer without azide.
Applicable Applications for Girdin Phospho-Regulation antibody sampler kit
Western Blot (WB), ELISA (EIA), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Immunoprecipitation (IP)
Preparation and Storage
Store all at -20 degree C. Stable for 1 year.
Related Product Information for Girdin Phospho-Regulation antibody sampler kit
Kit Summary: The Girdin phospho-regulation antibody sampler kit can be used to detect phosphorylation of Ser-1416, Ser-1674 and Tyr-1764 relative to total Girdin expression levels. The kit includes rabbit polyclonal, phospho-specific antibodies to Ser-1416, Ser-1674, and Tyr-1764, as well as a mouse monoclonal antibody to detect total Girdin epxression. The kit alsoincludes secondary reagents for detection of these antibodies in Western blot, ELISA, or immunocytochemistry.
Background: Girdin, a member of the CCDC88 (Hook related protein) family, is an actin binding protein involved with cell migration andmaintaining cytoskeletal organization. Girdin has conserved domains at the N- and C-terminus that bind microtubules andactin, respectively. It enhances PI3-kinase dependent phosphorylation of proteins, most notably Akt. This same activitycan contribute to tumor proliferation, invasion, and metastasis in breast, ovarian, prostate, and pancreatic tissues. Girdinis phosphorylated at three separate locations: Ser-1416, Ser-1674, and Tyr-1764. Ser-1416 is the primary Aktphosphorylation site, while Cyclin-dependent kinases interact with Girdin and phosphorylate Ser-1674. Multiple receptortyrosine kinases can bind girdin and phosphorylate Tyr-1764.
Background: Girdin, a member of the CCDC88 (Hook related protein) family, is an actin binding protein involved with cell migration andmaintaining cytoskeletal organization. Girdin has conserved domains at the N- and C-terminus that bind microtubules andactin, respectively. It enhances PI3-kinase dependent phosphorylation of proteins, most notably Akt. This same activitycan contribute to tumor proliferation, invasion, and metastasis in breast, ovarian, prostate, and pancreatic tissues. Girdinis phosphorylated at three separate locations: Ser-1416, Ser-1674, and Tyr-1764. Ser-1416 is the primary Aktphosphorylation site, while Cyclin-dependent kinases interact with Girdin and phosphorylate Ser-1674. Multiple receptortyrosine kinases can bind girdin and phosphorylate Tyr-1764.
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Product Notes
The Human, Rat, Mouse Girdin Phospho-Regulation (Catalog #AAA474368) is an Antibody Sampler Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA474368 Antibody Sampler Kit recognizes Human, Rat, Mouse Girdin Phospho-Regulation. AAA Biotech's Girdin Phospho-Regulation can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the Girdin Phospho-Regulation for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Girdin Phospho-Regulation, Antibody Sampler Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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