Testing Data
(Image: Paraffin-embedded human astrocytoma showing staining for c-Jun. Data courtesy of Cell Signaling Technology, Inc..More Links:)
c-Jun Antibody | anti-c-Jun antibody
c-Jun, Monoclonal Antibody, Rabbit
Gene Names
JUN; C-JUN
Reactivity
Human, Mouse, Primate, Rat
Applications
Immunohistochemistry, Western Blot, Immunoprecipitation
Synonyms
c-Jun; Monoclonal Antibody; Rabbit; anti-c-Jun antibody
Reactivity
Human, Mouse, Primate, Rat
Form/Format
Affinity Purified - Liquid
Sequence Length
331
Applicable Applications for anti-c-Jun antibody
Immunohistochemistry (IHC), Western Blot (WB), Immunoprecipitation (IP)
Type Info
Rabbit IgG
Immunogen
Peptide derived from the amino-terminal sequence of human c-Jun
Testing Data
(Image: Paraffin-embedded human astrocytoma showing staining for c-Jun. Data courtesy of Cell Signaling Technology, Inc..More Links:)
Testing Data
(Image: Paraffin-embedded human astrocytoma showing staining for c-Jun. Data courtesy of Cell Signaling Technology, Inc..More Links:)
Testing Data
(Image: Western blot analysis of extracts from NIH/3T3 and SK-N-MC cells, untreated or UV-treated.)
Testing Data
(Image: Western blot analysis of extracts from NIH/3T3 and SK-N-MC cells, untreated or UV-treated.)
Related Product Information for anti-c-Jun antibody
c-Jun is a component of the transcription factor AP-1, which binds and activates transcription at TRE/AP-1 elements. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73 (1,2). Extracellular signals including growth factors, transforming oncoproteins and UV irradiation stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun-dependent transcription. Mutation of Ser63/73 renders c-Jun nonresponsive to mitogenic and stress-induced signaling pathways. The MAP kinase homologue SAPK/JNK binds to the amino-terminal region of c-Jun and phosphorylates c-Jun at Ser63/73. In addition, the activity of SAPK/JNK is stimulated by the same signals that activate c-Jun (3,4).
c-Jun also plays a role in Neuropathic Pain.
c-Jun also plays a role in Neuropathic Pain.
Product Categories/Family for anti-c-Jun antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
35,629 Da
NCBI Official Full Name
c-Jun
NCBI Official Symbol
JUN
NCBI Official Synonym Symbols
C-JUN
NCBI Protein Information
transcription factor AP-1
UniProt Protein Name
Transcription factor AP-1
Protein Family
UniProt Gene Name
JUN
UniProt Synonym Gene Names
AP1
UniProt Entry Name
JUN_PIG
Uniprot Description
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells. Binds to the USP28 promoter in colorectal cancer (CRC) cells.
Research Articles on c-Jun
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Product Notes
The c-Jun jun (Catalog #AAA555002) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The c-Jun, Monoclonal Antibody, Rabbit reacts with Human, Mouse, Primate, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's c-Jun can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the c-Jun jun for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "c-Jun, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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