TNF-R1:Fc Active Protein
TNF-R1:Fc, Recombinant, Human (p55, CD120a, TNFRSF 1A, Tumor Necrosis Factor Receptor Superfamily Member 1A, TNF Receptor 1)
Purity
Highly Purified>95% (SDS-PAGE)
Synonyms
TNF-R1:Fc; Recombinant; Human (p55; CD120a; TNFRSF 1A; Tumor Necrosis Factor Receptor Superfamily Member 1A; TNF Receptor 1); TNF-R1:Fc active protein
Host
Human, HEK 293 cells
Specificity
Binds human and mouse TNF-alpha.
Purity/Purification
Highly Purified
>95% (SDS-PAGE)
>95% (SDS-PAGE)
Form/Format
Supplied as a lyophilized powder from a 0.2um filtered solution in PBS pH 7.2.
Sequence
The extracellular domain of human TNF-R1 (aa 22-211) is fused to the Fc portion of human IgG1.
Biological Activity
TNF-R1:Fc fusion protein blocks TNF-alpha-mediated biological effect with an inhibitory activity in a concentration range of 0.1 to 1ug/ml.
Preparation and Storage
Short-term Storage: +4 degree C
Long-term Storage: -20 degree C
Stable for at least 6 months after receipt when stored at -20 degree C.
Long-term Storage: -20 degree C
Stable for at least 6 months after receipt when stored at -20 degree C.
Related Product Information for TNF-R1:Fc active protein
TNF-R1 is a receptor for TNF-alpha and homotrimeric lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
Product Categories/Family for TNF-R1:Fc active protein
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Product Notes
The TNF-R1:Fc (Catalog #AAA637648) is an Active Protein produced from Human, HEK 293 cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: The extracellu lar domain of human TNF-R1 (aa 22-211) is fused to the Fc portion of human IgG1. It is sometimes possible for the material contained within the vial of "TNF-R1:Fc, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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