Human Transthyretin/TTR ELISA Kit | TTR elisa kit

Human Transthyretin/TTR PicoKine ELISA Kit

Cat. Num. AAA1751591

• Gene Names: TTR; CTS; ATTR; CTS1; PALB; TBPA; HEL111; HsT2651
• Reactivity: Human
• Synonyms: Transthyretin/TTR; Human Transthyretin/TTR PicoKine ELISA Kit; Human TTR; TTR elisa kit

• Reactivity: Human
• Specificity: Natural and recombinant Human TREML2
• Sequence Length: 147

• Samples: Cell Culture Supernates, Serum And Plasma (Heparin, Edta)
• Detection Range: 62.5pg/ml-4000pg/ml
• Sensitivity: <10pg/ml
• Intra-assay Precision: Intra-Assay Precision (Precision within an assay): Three samples of known concentration were tested on one plate to assess intra-assay precision
• Inter-assay Precision: Inter-Assay Precision (Precision accross assays):Three samples of known concentration were tested in separate assays to assess inter-assay precision.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for TTR elisa kit

Principle of the Assay: The Picokine Human TREML2 Pre-Coated ELISA (Enzyme-Linked Immunosorbent Assay) kit is a solid phase immunoassay specially designed to measure Human TREML2 with a 96-well strip plate that is pre-coated with antibody specific for TREML2. The detection antibody is a biotinylated antibody specific for TREML2. The capture antibody is A monoclonal antibody from mouse, the detection antibody is a biotinylated detection polyclonal antibody from goat. The kit contains recombinant Human TREML2 with immunogen: Expression system for standard: E.coli, Immunogen sequence: G19-S268. The kit is analytically validated with ready to use reagents. To measure Human TREML2, add standards and samples to the wells, then add the biotinylated detection antibody. Wash the wells with PBS or TBS buffer, and add Avidin-Biotin-Peroxidase Complex (ABC-HRP). Wash away the unbounded ABC-HRP with PBS or TBS buffer and add TMB. TMB is substrate to HRP and will be catalyzed to produce a blue color product, which changes into yellow after adding acidic stop solution. The density of the yellow product is linearly propotional to Human TREML2 in the sample. Read the density of the yellow product in each well using a plate reader, and benchmark the sample wells' readings against the standard curve to determine the concentration of Human TREML2 in the sample!!Background/Introduction: TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties. This gene is mapped to 6p21.1.

NCBI and Uniprot Product Information

• NCBI GI #: 4507725
• NCBI GeneID: 7276
• NCBI Accession #: NP_000362.1
• NCBI GenBank Nucleotide #: NM_000371.3
• UniProt Accession #: P02766
• NCBI Official Full Name: transthyretin
• NCBI Official Synonym Full Names: transthyretin
• NCBI Official Symbol: TTR
• NCBI Official Synonym Symbols: CTS; ATTR; CTS1; PALB; TBPA; HEL111; HsT2651
• NCBI Protein Information: transthyretin
• Protein Family: Transthyretin

NCBI Description

This gene encodes one of the three prealbumins, which include alpha-1-antitrypsin, transthyretin and orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier protein, which transports thyroid hormones in the plasma and cerebrospinal fluid. It is also involved in the transport of retinol (vitamin A) in the plasma by associating with retinol-binding protein. The protein may also be involved in other intracellular processes including proteolysis, nerve regeneration, autophagy and glucose homeostasis. Mutations in this gene are associated with amyloid deposition, predominantly affecting peripheral nerves or the heart, while a small percentage of the gene mutations are non-amyloidogenic. The mutations are implicated in the etiology of several diseases, including amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis and carpal tunnel syndrome. [provided by RefSeq, Aug 2017]